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Pediatric Epidemiology of Cardiovascular Disease Risk Factors (Project Heartbeat)

This study has been completed.
Sponsor:
Information provided by:
National Heart, Lung, and Blood Institute (NHLBI)
ClinicalTrials.gov Identifier:
NCT00005264
First received: May 25, 2000
Last updated: June 23, 2005
Last verified: October 2002

May 25, 2000
June 23, 2005
September 1990
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Complete list of historical versions of study NCT00005264 on ClinicalTrials.gov Archive Site
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Pediatric Epidemiology of Cardiovascular Disease Risk Factors (Project Heartbeat)
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To conduct a longitudinal, natural history study of cardiovascular disease risk factors in children. Growth curves were compared for levels of blood pressure, lipids, cardiac structures and function, and related to physical growth and maturation, nutrient intake, physical activity, body composition, puberty, and smoking.

BACKGROUND:

Both the pathologic precursors of atherosclerosis and the development of its major risk factors -- blood pressure, blood lipids, and cigarette smoking -- are often far advanced before age 20 or within the period from birth or conception through adolescence. In 1990, there was growing interest in understanding these aspects of human biology and in devising appropriate preventive measures.

In 1990, knowledge about the risk factors during childhood and adolescence was based mainly on cross-sectional surveys, from which very striking and consistent patterns of change with age were inferred, and from which reference values for screening and management were derived. Both growth and sexual maturation influence these patterns strongly, yet these risk factors had only recently been taken into account in 1990, only partially in screening recommendations for blood pressure and not at all for cholesterol.

DESIGN NARRATIVE:

Subjects were selected by simple random sampling. Data were collected on dependent variables including blood pressure, heart rate, echocardiography, Doppler flow, blood lipids, and smoking. Independent variables included growth, diet and nutrition, electrolytes, physical activity and fitness, personal, family, and social history, and bone age. Most observations were recorded at four month intervals. There was a six month pretest recruitment period, four years of cycled measurements and data collection, and six months of analysis and reporting. Curves for both velocity and acceleration of growth for attained levels of blood pressure, blood lipids, and smoking were determined as were longitudinal relationships between individual growth curves of blood pressure, echocardiographic measures, physical growth, sexual maturation, body composition, diet, physical activity, and social factors.

Dr. Labarthe has several R03 grants to analyze data from Project Heartbeat. See also Study 4962.

Observational
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  • Cardiovascular Diseases
  • Heart Diseases
  • Atherosclerosis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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September 1996
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No eligibility criteria

Male
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No
Contact information is only displayed when the study is recruiting subjects
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NCT00005264
1148
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National Heart, Lung, and Blood Institute (NHLBI)
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Investigator: Darwin LaBarthe University of Texas
National Heart, Lung, and Blood Institute (NHLBI)
October 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP