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Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children

This study has been completed.
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004638
First received: February 23, 2000
Last updated: June 23, 2005
Last verified: November 2001

February 23, 2000
June 23, 2005
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Complete list of historical versions of study NCT00004638 on ClinicalTrials.gov Archive Site
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Immunologic Aspects of the Pathogenesis of Chronic Sinusitis in Children
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Chronic sinusitis is a common pediatric disease; it ranks among the top five infectious diseases of the upper respiratory tract. Its treatment is limited and may be due largely in part to a lack of understanding of its cause. The investigators have preliminary data to support the notion that pediatric chronic sinusitis is a distinct disease, different from acute sinusitis and adult chronic sinusitis. We are proposing to perform pathogenesis studies in children with chronic sinusitis. Specifically, we wish to elucidate the microbiologic features and immunologic factors involved in the formation of this disease. The study plan calls for microbiologic (bacterial, viral, and fungal) and immunologic (inflammatory mediators and leukocyte populations) data to be evaluated through a maxillary sinus washing and mucosal biopsies. Four populations will be studied and they are: 10 children with chronic sinusitis, 5 children with acute sinusitis (positive control), 5 children without sinusitis (negative control) and 5 adults with chronic sinusitis (positive secondary control).

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Interventional
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Primary Purpose: Diagnostic
Sinusitis
Procedure: pathogenesis study
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • chronic sinusitis confirmed by imaging study for greater than 12 weeks subjects have failed medical therapy
Both
up to 18 Years
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004638
NCRR-M01RR00069-0609, M01RR00069
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National Center for Research Resources (NCRR)
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National Center for Research Resources (NCRR)
November 2001

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP