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Incorporating Flow Limitation Into the Diagnosis and Quantification of Sleep Disordered Breathing

This study has been completed.
Sponsor:
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004569
First received: February 12, 2000
Last updated: June 23, 2005
Last verified: January 2004

February 12, 2000
June 23, 2005
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Complete list of historical versions of study NCT00004569 on ClinicalTrials.gov Archive Site
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Incorporating Flow Limitation Into the Diagnosis and Quantification of Sleep Disordered Breathing
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The diagnosis and treatment of sleep disordered breathing have come to the forefront of clinical medicine following recognition of the high prevalence and associated morbidity of sleep apnea. The effects on quality of life as well as societal costs have been well documented. The NYU Sleep Research Laboratory has spent the last several years working on the problem of improving the diagnosis of mild sleep disordered breathing which manifests as the upper airway resistance syndrome. Our approach has been to develop a non-invasive technique to detect increased upper airway resistance directly from analysis of the airflow signal. A characteristic intermittent change of the inspiratory flow contour, which is indicative of the occurrence of flow limitation, correlates well with increased airway resistance.

Currently all respiratory events are identified manually and totaled. This is time consuming and subject to variability. The objective of the present project is to improve upon the manual approach by implementing an artificially intelligent system for the identification and quantification of sleep disordered breathing based solely on non-invasive cardiopulmonary signals collected during a routine sleep study. The utility of other reported indices of sleep disordered breathing obtained during a sleep study will be evaluated.

Successful development of an automated system that can identify and classify upper airway resistance events will simplify, standardize and improve the diagnosis of sleep disordered breathing, and greatly facilitate research and clinical work in this area. Using a physiological based determination of disease should allow better assessment of treatment responses in mild disease.

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Interventional
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Primary Purpose: Diagnostic
Sleep-Disordered Breathing
Procedure: Non-invasive technique to diagnose and quantitate sleep-disordered breathing
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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Inclusion Criteria:

  • Patients with sleep disordered breathing
Both
18 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004569
NCRR-M01RR00096-0938, M01RR00096
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National Center for Research Resources (NCRR)
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National Center for Research Resources (NCRR)
January 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP