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Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope

This study has been completed.
Sponsor:
Information provided by:
Office of Rare Diseases (ORD)
ClinicalTrials.gov Identifier:
NCT00004479
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: July 2004

October 18, 1999
June 23, 2005
March 1999
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Complete list of historical versions of study NCT00004479 on ClinicalTrials.gov Archive Site
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Randomized Study of Midodrine, an Alpha Adrenergic Agonist, in Patients With Neurally Mediated Syncope
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OBJECTIVES:

Determine the efficacy of midodrine, a selective alpha 1 adrenergic agonist, in preventing neurally mediated syncope.

PROTOCOL OUTLINE: This is a randomized, double-blind, crossover, placebo-controlled study.

On day one, patients receive either midodrine or placebo. On day three, patients receive the opposite drug.

Interventional
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Allocation: Randomized
Masking: Double-Blind
Primary Purpose: Treatment
Syncope
Drug: midodrine
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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PROTOCOL ENTRY CRITERIA:

--Disease Characteristics-- Diagnosis of neurally mediated syncope (vasovagal fainting) Sudden fall in blood pressure AND Slowing of the heart AND Temporary loss of consciousness AND Hemodynamic response to head up tilt --Prior/Concurrent Therapy-- No other concurrent adrenergic agonist or antiagonist --Patient Characteristics-- Fertile patients must use effective birth control

Both
16 Years and older
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004479
199/14181, MTS-GCO-97-160NE, ROBERTS-MTS-GCO-97-160NE
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Mount Sinai School of Medicine
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Study Chair: Horacio Kaufmann Mount Sinai School of Medicine
Office of Rare Diseases (ORD)
July 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP