Study of the Neurobiology of Tourette Syndrome and Related Disorders

This study has been completed.
Sponsor:
Collaborator:
Yale University
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004325
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: January 2004

October 18, 1999
June 23, 2005
December 1988
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Complete list of historical versions of study NCT00004325 on ClinicalTrials.gov Archive Site
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Study of the Neurobiology of Tourette Syndrome and Related Disorders
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OBJECTIVES: I. Investigate the pathobiology of Tourette syndrome and related disorders by measuring various compounds of interest in cerebrospinal fluid, plasma, and urine of patients with Tourette syndrome, obsessive compulsive disorder, and/or chronic tics.

II. Determine the pattern of familial aggregation of Tourette syndrome and obsessive compulsive disorder by systematic assessment of all first-degree family members of patients selected for cerebrospinal fluid studies.

III. Establish the neurochemical and neuropeptide profile associated with the range of expression of the putative Tourette gene expression in adult and adolescent patients.

PROTOCOL OUTLINE: All patients are screened with a complete physical and neurologic exam, and a semi-structured interview. Patients then receive a comprehensive assessment of systemic disease. Patients and first-degree family members also participate in a genetic study.

Any patient who experiences an unusual exacerbation of symptoms or significant side effects is removed from the study.

Observational
Primary Purpose: Screening
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  • Tourette Syndrome
  • Obsessive Compulsive Disorder
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
200
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PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Diagnostic and Statistical Manual of Mental Disorders IV lifetime diagnosis of 1 or more of the following:

  • Tourette syndrome (TS)
  • Obsessive compulsive disorder
  • Chronic tics

Severely affected adolescents with a score of 3 or greater on the TS-Clinical Global Impression Scale eligible

--Prior/Concurrent Therapy--

At least 1 month since any medication

--Patient Characteristics--

Other:

  • In good physical health
  • No alcohol or substance abuse
  • No Intelligence Quotient below 80
  • Negative pregnancy test required of fertile women
Both
12 Years to 45 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004325
199/11866, YALESM-4601
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National Center for Research Resources (NCRR)
Yale University
Study Chair: James F. Leckman Yale University
National Center for Research Resources (NCRR)
January 2004

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP