Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

This study has been completed.
Sponsor:
Collaborators:
Ohio State University
Information provided by:
National Center for Research Resources (NCRR)
ClinicalTrials.gov Identifier:
NCT00004305
First received: October 18, 1999
Last updated: June 23, 2005
Last verified: April 2002

October 18, 1999
June 23, 2005
January 1998
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Complete list of historical versions of study NCT00004305 on ClinicalTrials.gov Archive Site
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Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis
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OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N).

II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.

PROTOCOL OUTLINE:

Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.

Observational
Primary Purpose: Screening
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IGA Glomerulonephritis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
105
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  • IgA glomerulonephritis
Both
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No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00004305
199/11791, OSU-94H0338
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National Center for Research Resources (NCRR)
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
  • Ohio State University
Study Chair: Lee A. Hebert Ohio State University
National Center for Research Resources (NCRR)
April 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP