Genetic Study in Patients With Stage II or Stage III Colon Cancer

This study has been completed.
Sponsor:
Collaborators:
NCIC Clinical Trials Group
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT00003833
First received: November 1, 1999
Last updated: February 6, 2009
Last verified: October 2002

November 1, 1999
February 6, 2009
February 1999
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Complete list of historical versions of study NCT00003833 on ClinicalTrials.gov Archive Site
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Genetic Study in Patients With Stage II or Stage III Colon Cancer
The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer

RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer.

PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.

OBJECTIVES:

  • Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer.
  • Determine if patient prognosis is dependent on the region of 8p AI.
  • Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p.
  • Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI.

OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.

PROJECTED ACCRUAL: Approximately 480 patients will be accrued for this study.

Observational
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Colorectal Cancer
  • Genetic: DNA stability analysis
  • Genetic: gene mapping
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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DISEASE CHARACTERISTICS:

  • Diagnosis of resectable stage II or III adenocarcinoma of the colon
  • Participated in NCCTG-914653
  • DNA extracted from both normal and tumor tissue

PATIENT CHARACTERISTICS:

Age

  • Under 70

Performance status

  • Not specified

Life expectancy

  • Not specified

Hematopoietic

  • Not specified

Hepatic

  • Not specified

Renal

  • Not specified

PRIOR CONCURRENT THERAPY:

Biologic therapy

  • Not specified

Chemotherapy

  • Not specified

Endocrine therapy

  • Not specified

Radiotherapy

  • Not specified

Surgery

  • Not specified
Both
up to 69 Years
No
Contact information is only displayed when the study is recruiting subjects
United States,   Canada
 
NCT00003833
CDR0000066990, NCCTG-984654, CAN-NCIC-CO9PATH
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North Central Cancer Treatment Group
  • National Cancer Institute (NCI)
  • NCIC Clinical Trials Group
Study Chair: Richard M. Goldberg, MD Mayo Clinic
Study Chair: Lois Shepherd, MD NCIC Clinical Trials Group
National Cancer Institute (NCI)
October 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP