Genetic Studies of Lysosomal Storage Disorders

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT00001215
First received: November 3, 1999
Last updated: March 20, 2014
Last verified: March 2014

November 3, 1999
March 20, 2014
May 1986
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Complete list of historical versions of study NCT00001215 on ClinicalTrials.gov Archive Site
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Genetic Studies of Lysosomal Storage Disorders
Studies of Genetic Heterogeneity in Patients With Lysosomal Storage Disorders

The purpose of this study is to identify genetic, biochemical, and clinical factors that are associated with disease severity in people with Gaucher disease and other lysosomal storage disorders.

There is a vast spectrum of clinical manifestations in people with Gaucher disease as well as other lysosomal storage disorders. This study will evaluate patients with lysosomal disorders on an outpatient or inpatient basis in order to better characterize the clinical, genetic, and pathophysiological features of these disorders. Participants will be re-evaluated on an annual basis.

There is a vast spectrum of clinical manifestations encountered in individuals with lysosomal storage diseases. Lysosomes are organelles that are involved in the degradation of intracellular proteins, recycled products and organelle in the cell. Lysosomal storage disorders occur when an enzyme necessary for breaking down these molecules is deficient, and, as a result, the substrate accumulates within the lysosomes of cells and may affect different organ systems. This is a longitudinal natural history study of patients with Gaucher disease and other storage disorders. Gaucher disease, the most common lysosomal storage disorder, results from the inherited deficiency of the enzyme glucocerebrosidase, which breaks down the lipid glucocerebroside. The disease is characterized by extremely variable phenotypes, with some patients presenting in childhood with virtually all the complications of Gaucher disease, while others remain asymptomatic into their eighth decade. Often patients with Gaucher disease develop hepatosplenomegaly, anemia, thrombocytopenia and bony problems. Gaucher disease has traditionally been divided into three clinical subtypes, delineated by the absence or presence of neurologic involvement and its progression:

Type 1 -Non-neuronopathic form

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Type 2 -Acute neuronopathic form

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Type 3 -Chronic neuronopathic form

Some patients, however, defy classification into these three categories, and it may be more accurate to regard Gaucher disease as a continuum of phenotypes. A recent finding is that patients and carriers for Gaucher disease are at increased risk for developing Parkinson disease and related disorders.

Our specific aim in this study is to identify genetic, biochemical, and clinical parameters that are associated with disease severity in individuals with lysosomal storage disorders and their relatives, and to explore the natural history and extent of associated clinical manifestations. We also want to investigate pre-motor manifestations in subjects at higher risk for developing parkinsonism that could contribute to earlier diagnosis. Participants will be evaluated at the NIH to better characterize the clinical, genetic and pathophysiological features of these disorders. In order to better understand the entire effect of the enzyme deficiencies and the function of the specific proteins involved, emphasis will be placed on individuals with atypical presentations. In particular, we will focus on subjects with Gaucher disease and parkinsonism, to better understand the association between the two disorders. Following an initial comprehensive workup, participants will be studied either in the inpatient wards or the outpatient clinic, and will be re-evaluated at approximately one-year intervals.

Observational
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  • Gaucher's Disease
  • Lysosomal Storage Disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
1000
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  • INCLUSION CRITERIA:

Participants must be found to have or be a carrier of a documented lysosomal storage disorder or be a family member of a documented proband.

Both
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Contact: Catherine A Groden, R.N. (301) 594-2951 cgroden@mail.nih.gov
Contact: Ellen Sidransky, M.D. (301) 451-0901 es30e@nih.gov
United States
 
NCT00001215
860096, 86-HG-0096
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National Human Genome Research Institute (NHGRI)
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Principal Investigator: Ellen Sidransky, M.D. National Human Genome Research Institute (NHGRI)
National Institutes of Health Clinical Center (CC)
March 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP