Alzheimer's Disease Prevention Trial - Tabular View

Tracking Information

First Received Date ^ICMJE

October 29, 1999

Last Updated Date

September 19, 2007

Start Date ^ICMJE

Primary Completion Date

Current Primary Outcome Measures ^ICMJE

Original Primary Outcome Measures ^ICMJE

Change History

Complete list of historical versions of study NCT00000176 on ClinicalTrials.gov Archive Site

Current Secondary Outcome Measures ^ICMJE

Original Secondary Outcome Measures ^ICMJE

Descriptive Information

Brief Title ^ICMJE

Alzheimer's Disease Prevention Trial

Official Title ^ICMJE

Alzheimer's Disease Prevention Trial. A Multi-Center, Randomized, Double-Blind Placebo Controlled Trial of Estrogens to Prevent Alzheimer's Disease and Loss of Memory in Women.

Brief Summary

This is a three-year study to determine if estrogens can prevent memory loss and Alzheimer's disease in women with a family history of Alzheimer's disease.

Detailed Description

PREventing Postmenopausal memory loss and Alzheimer's with Replacement Estrogens (PREPARE) is a double-blind-placebo controlled trial to determine whether estrogen (or estrogen and progesterone) can delay the onset of memory loss or Alzheimer's Disease in elderly women with a family history of the disease.

Study Phase

Phase III

Study Type ^ICMJE

Interventional

Study Design ^ICMJE

Prevention, Randomized, Double-Blind, Placebo Control

Condition ^ICMJE

Alzheimer Disease
Memory Disorders

Intervention ^ICMJE

Drug: Estrogen
Drug: Estrogen and Progesterone

Study Arms / Comparison Groups

Publications *

* Includes publications given by the data provider as well as publications identified by National Clinical Trials Identifier (NCT ID) in Medline.

Recruitment Information

Recruitment Status ^ICMJE

Completed

Enrollment ^ICMJE

Completion Date

December 2010

Primary Completion Date

Eligibility Criteria ^ICMJE

Inclusion Criteria:

Healthy women 65 or older with a family history of memory problems not currently on estrogen.

Exclusion Criteria:

Significant neurological impairment
Current estrogen use
History of breast cancer

Gender

Female

Ages

65 Years and older

Accepts Healthy Volunteers

Yes

Contacts ^ICMJE

Contact information is only displayed when the study is recruiting subjects

Location Countries ^ICMJE

United States

Administrative Information

NCT ID ^ICMJE

NCT00000176

Responsible Party

Study ID Numbers ^ICMJE

IA0018, RO 1AG15922-01

Study Sponsor ^ICMJE

National Institute on Aging (NIA)

Collaborators ^ICMJE

Investigators ^ICMJE

Principal Investigator:

Mary Sano, PhD

Mount Sinai School of Medicine

Information Provided By

National Institute on Aging (NIA)

Verification Date

September 2007

^ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP