KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease (KNOW-PedCKD)
The goals of the KNOW-pedCKD (KoreaN cohort study for Outcome in Pediatric patients With Chronic Kidney Disease) study are 1) to establish a CKD cohort representing Korean pediatric CKD population for up to 10-year follow-up, and 2) to investigate the renal progression, mortality, complications, risk factors, role of biochemical parameters and the genetic influence.
KNOW-pedCKD Research Group comprises nephrologists, pediatric nephrologists, epidemiologists and statisticians from eleven centers in Korea. KNOW-pedCKD will enroll individuals with CKD stage from 1 to 5 between 2011 and 2015 and follow them up to 10 years. Dialyzed patients or those with allograft kidney are excluded. At enrollment and at pre-specified intervals, laboratory tests will be conducted on the kidney function, biochemical profiles, anemia, cardiovascular complication (echocardiography, coronary CT, arterial stiffness), and mineral bone disorder. A biobank is also established for the DNA, serum and urine at regular interval. Information on the medical history, health questionnaires, QoL will also be collected. Web-based case-report forms (CRF) is developed for the systemic management of the patient data.
Chronic Kidney Disease(CKD)
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||KoreaN Cohort Study for Outcome in Pediatric Patients With Chronic Kidney Disease : A 10-year Longitudinal Cohort Study of the Chronic Kidney Disease|
- Overall mortality [ Time Frame: 10 years ] [ Designated as safety issue: No ]
- Cardiovascular event [ Time Frame: 10 years ] [ Designated as safety issue: No ]
- Renal replacement therapy [ Time Frame: 10 years ] [ Designated as safety issue: No ]dialysis or kidney transplantation
- Change in serum creatinine [ Time Frame: 10 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
A biobank is also established for the DNA, serum and urine taken at regular interval.
|Study Start Date:||March 2011|
|Estimated Study Completion Date:||December 2021|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Children and adolescent
children and adolescent CKD patients of any etiology
Please refer to this study by its ClinicalTrials.gov identifier: NCT02165878
|Korea, Republic of|
|Seoul National University Hospital||Recruiting|
|Seoul, Korea, Republic of, 110-744|
|Contact: Il Soo Ha 82-2-2072-3584 firstname.lastname@example.org|
|Contact: Hee Gyung Kang email@example.com|