An Open-label Trial of 48-week Peginterferon Alfa-2a (PEGASYS) to Assess the Sustained Response of Chronic Hepatitis B Patients With HBeAg Seroconversion on Nucleot(s)Ide Analogue Therapy

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by Chinese University of Hong Kong
Sponsor:
Information provided by (Responsible Party):
Henry LY Chan, Chinese University of Hong Kong
ClinicalTrials.gov Identifier:
NCT02068365
First received: January 28, 2014
Last updated: February 19, 2014
Last verified: February 2014
  Purpose

This is a multi-center, single-arm, open-label study on the virological response of chronic HBV infection to pegyinterferon-alfa-2a among patients who achieved HBeAg seroconversion on nucleos(t)ide analogue (NA) treatment. The primary endpoint of this study is to investigate the sustained response (HBeAg seroconversion with HBV DNA <2000 IU/ml) to peginterferon at 24 weeks after the end of treatment.


Condition Intervention Phase
Chronic Hepaititis B
Drug: Pegyinterferon-alfa-2a
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:


Further study details as provided by Chinese University of Hong Kong:

Primary Outcome Measures:
  • Sustained response (HBeAg seroconversion and HBV DNA <2000 IU/ml) [ Time Frame: 24 weeks post-treatment ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • HBeAg loss and seroconversion [ Time Frame: 24 weeks post-treatment and follow up for 5 years. ] [ Designated as safety issue: No ]
  • HBsAg loss and seroconversion [ Time Frame: 24 weeks post-treatment and follow up for 5 years. ] [ Designated as safety issue: No ]
  • HBV DNA <2000IU/ml and undetectable [ Time Frame: 24 weeks post-treatment and follow up for 5 years. ] [ Designated as safety issue: No ]
  • ALT normalization [ Time Frame: 24 weeks post-treatment and long-term follow-up ] [ Designated as safety issue: No ]
  • Sustained response [ Time Frame: 5 years post treatment ] [ Designated as safety issue: No ]

Estimated Enrollment: 20
Study Start Date: June 2013
Estimated Primary Completion Date: June 2020 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Pegyinterferon-alfa-2a
Pegyinterferon-alfa-2a 180mcq weekly for 48 weeks
Drug: Pegyinterferon-alfa-2a
Pegyinterferon-alfa-2a 180mcq weekly for 48 weeks

Detailed Description:

Chronic hepatitis B is the commonest cause of liver cirrhosis and hepatocellular carcinoma in Hong Kong. Treatment with interferon and nucleos(t)ide analogues (NA) can reduce the risk of HCC. NA is the commonest used medication in Hong Kong. However, most patients require long-term treatment and premature drug cessation may lead to hepatitis relapse.

Under the current regional guidelines, patients who have positive hepatitis B e antigen (HBeAg) treated by NA can consider stopping treatment if HBeAg seroconversion has developed for at least 12 months. However, up to 30-50% of patients may develop virological relapse and/or HBeAg reversion after cessation of treatment. On the other hand, interferon-based treatment has a much more durable response. HBeAg seroconversion is maintained in 80% of patients after successful treatment with peginterferon. Upon long-term follow-up, peginterferon-treated patients are also more likely to achieve hepatitis B surface antigen (HBsAg) seroclearance, a condition closest to a cure of chronic hepatitis B.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male and female patients >= 18 and < 70 years of age
  • Positive HBeAg before starting NA treatment
  • Treated by a single NA (lamivudine, adefovir, entecavir or tenofovir) for 6 months to 5 years
  • Developed HBeAg seroconversion (HBeAg negative and ant-HBe negative) with undetectable HBV DNA by PCR based assay on NA treatment.
  • Negative urine or serum pregnancy test (for women of childbearing potential) documented within the 24-hour period prior to the first dose of test drug. Additionally, all females must be using reliable contraception during the study and for 3 months after treatment completion

Exclusion Criteria:

  • Evidence of decompensated liver disease (Childs B-C), hepato-cellular carcinoma, pre-existing severe depression or other psychiatric disease, significant cardiac disease, significant renal disease, seizure disorders or severe retinopathy.
  • received telbivudine as the antiviral therapy or have received more than one NA in the past.
  • received interferon or peginterferon treatment in the past.
  • received antiviral therapy for any systemic anti-viral, anti-neoplastic or immuno-modulatory treatment (including supraphysiologic doses of steroids and radiation) within the past 6 months.
  • Positive test at screening for anti-HIV, anti-HCV.
  • Patients who are expected to need systemic antiviral therapy other than that provided by the study at any time during their participation in the study are also excluded. Exception: patients who have had a limited (<=7 days) course of acyclovir for herpetic lesions more than 1 month prior to the first administration of test drug are not excluded.
  • Serum total bilirubin > 3 times the upper limit of normal at screening.
  • History or other evidence of bleeding from esophageal varices or other conditions consistent with decompensated liver disease.
  • History or other evidence of a medical condition associated with chronic liver disease other than HBV (e.g., hemochromatosis, autoimmune hepatitis, metabolic liver diseases including Wilson's and alpha1-antitrypsin deficiency, alcoholic liver disease, toxin exposures, thalassemia).
  • Women with ongoing pregnancy or who are breast feeding.
  • Neutrophil count <1500 cells/mm3 or platelet count <90,000 cells/mm3 at screening.
  • Hemoglobin < 11.5 g/dL for females and < 12.5 g/dL for men at screening.
  • Serum creatinine level >120 umol/ml for men and >105 umol/ml for women at screening.
  • History of severe psychiatric disease, especially depression. Severe psychiatric disease is defined as major depression or psychosis, a period of treatment with an antidepressant medication or major tranquilizer at therapeutic doses for depression or psychosis for at least 3 months, a suicidal attempt, hospitalization for psychiatric disease, or a period of disability due to a psychiatric disease.
  • History of immunologically mediated disease (e.g., inflammatory bowel disease, idiopathic thrombocytopenic purpura, lupus erythematosus, autoimmune hemolytic anemia, scleroderma, severe psoriasis, rheumatoid arthritis).
  • History or other evidence of chronic pulmonary disease associated with functional limitation. Severe cardiac disease (e.g., NYHA Functional Class III or IV, myocardial infarction within 6 months, ventricular tachyarrhythmias requiring ongoing treatment, unstable angina or other significant cardiovascular diseases).
  • History of a severe seizure disorder or current anticonvulsant use.
  • Evidence of an active or suspected cancer or a history of malignancy where the risk of recurrence is >=20% within 2 years. Patients with a lesion suspicious of hepatic malignancy on a screening imaging study will only be eligible if the likelihood of carcinoma is <=10% following an appropriate evaluation.
  • History of having received any systemic anti-neoplastic (including radiation) or immunomodulatory treatment (including systemic corticosteroids) <=6 months prior to the first dose of study drug or the expectation that such treatment will be needed at any time during the study.
  • Major organ transplantation.
  • Thyroid disease with thyroid function poorly controlled on prescribed medications. Patients with abnormal thyroid stimulating hormone or T4 concentrations, with elevation of antibodies to thyroid peroxidase and any clinical manifestations of thyroid disease are excluded.
  • History or other evidence of severe retinopathy (e.g. CMV retinitis, macula degeneration) or clinically relevant ophthalmological disorder due to diabetes mellitus or hypertension
  • Inability or unwillingness to provide informed consent or abide by the requirements of the study.
  • History or other evidence of severe illness or any other conditions which would make the patient, in the opinion of the investigator, unsuitable for the study.
  • Patients with a value of alpha-fetoprotein >100 ng/mL are excluded, unless stability (less than 10% increase) has been documented over at least the previous 3 months.
  • Evidence of drug and/or alcohol abuse (20g/day for women and 30g/day for men).
  • Patients included in another trial or having been given investigational drugs within 12 weeks prior to screening
  • Any known history of hypersensitivity to interferon.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT02068365

Contacts
Contact: Angel ML Chim, MSc +852 2632 4205 angelchim@cuhk.edu.hk

Locations
China
Prince of Wales Hospital Recruiting
Hong Hong, China
Sub-Investigator: Vincent WS Wong, MD         
Sub-Investigator: Grace LH Wong, MD         
Sponsors and Collaborators
Chinese University of Hong Kong
Investigators
Principal Investigator: Henry LY Chan, MD Chinese University of Hong Kong
  More Information

Publications:

Responsible Party: Henry LY Chan, Professor, Chinese University of Hong Kong
ClinicalTrials.gov Identifier: NCT02068365     History of Changes
Other Study ID Numbers: ML28486
Study First Received: January 28, 2014
Last Updated: February 19, 2014
Health Authority: Hong Kong: Department of Health

Additional relevant MeSH terms:
Hepatitis B, Chronic
Hepatitis B
Hepatitis, Viral, Human
Hepatitis, Chronic
Hepatitis
Hepadnaviridae Infections
DNA Virus Infections
Virus Diseases
Liver Diseases
Digestive System Diseases
Peginterferon alfa-2a
Antiviral Agents
Anti-Infective Agents
Therapeutic Uses
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 24, 2014