Epigenetic Influences on Post-Surgical Acute and Chronic Pain
Pain is the way our brain interprets certain bodily sensations. It is very difficult to describe or to put into words as perception and tolerance of pain varies widely between individuals. It is known that age, gender and past experience and memory of past experience all contribute to patients' feelings of discomfort and tolerance of pain, but the reason why some patients actually do not experience any pain at all post surgery is still unknown.
Because pain affects every person at some point in their lives, it is of utmost importance that we can find more effective analgesic methods, and provide analgesia tailored to an individual's need as well as discovering new methods which may be able to identify those individuals who are more prone to suffering serious, or chronic pain. It has been proposed that epigenetic modifications may play a role in sensitivity to analgesia and response to trauma, such as post surgery. The effects of epigenetic changes on key genes and the role this plays in analgesia sensitivity and pain perception is deserving of further research.
Epigenetics is a growing field of study in which there are genetic modifications that do not involve changes to base sequences in a gene, but that result nonetheless in changes to gene expression. It has long been known that changes in gene expression play an important role in the establishment of pain states. But it is not known whether a priming injury can induce lasting epigenetic marks which would result in an increase in both postoperative acute pain and the risk for chronic pain. Only by fully understanding these epigenetic mechanisms will we be able to offer better drugs for the treatment of pain, and to identify those at high risk of postoperative pain and postsurgical chronic pain.
The purpose of this study is to determine whether severity of pain following surgical procedures, such as third molar surgery is related to baseline methylation status of the promoter region of IL-6 and TNF-α and changes in methylation status post surgery.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||An Exploratory Study of the Epigenetic Influences on Post-Surgical Acute and Chronic Pain|
- pain score [ Time Frame: From postoperative 1 hour to postoperative 3 months ] [ Designated as safety issue: No ]
- IL-6 and TNF-α expression [ Time Frame: From postoperative 1 hr to postoperative 3 month ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
RNA and DNA
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||November 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
patients undergo third molar surgery
subjects do not require surgery
Show Detailed Description
Please refer to this study by its ClinicalTrials.gov identifier: NCT02002520
|Contact: Chi W Cheung||852 firstname.lastname@example.org|
|Department of Anaesthesiology, The University of Hong Kong||Recruiting|
|Hong Kong, Hong Kong, 0000|
|Contact: Yvonne Lee, MPhil 852-22553303 email@example.com|
|Department of Anaesthesiology, The University of Hong Kong||Not yet recruiting|
|Hong Kong, Hong Kong, 0000|
|Contact: Chi W Cheung 852 22553303 firstname.lastname@example.org|
|Principal Investigator:||Chi W Cheung||Department of Anaesthesiology, The University of Hong Kong|