The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

This study is currently recruiting participants.
Verified November 2013 by Karolinska Institutet
Sponsor:
Collaborator:
Stockholm University
Information provided by (Responsible Party):
Mats Lekander, Karolinska Institutet
ClinicalTrials.gov Identifier:
NCT02000076
First received: August 13, 2013
Last updated: November 26, 2013
Last verified: November 2013
  Purpose

The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation. A full description, including hypothese, can be found at https://openscienceframework.org/project/bXFSB/


Condition Intervention
Sleep Deprivation
Behavioral: Partial sleep deprivation allowing 3 h sleep at night

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Further study details as provided by Karolinska Institutet:

Primary Outcome Measures:
  • Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping) [ Time Frame: Change between 1st and 2nd MRI scanning session (approx. 1 month later) ] [ Designated as safety issue: No ]
    This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).


Estimated Enrollment: 30
Study Start Date: November 2012
Estimated Study Completion Date: October 2014
Estimated Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sleep deprivation
Partial sleep deprivation allowing 3 h sleep at night
Behavioral: Partial sleep deprivation allowing 3 h sleep at night
Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
Other Names:
  • Sleep restriction
  • Sleep loss

  Eligibility

Ages Eligible for Study:   20 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 20-30 years of age, inclusive
  • Able to understand spoken and written Swedish (in order to understand instructions)
  • Normal or corrected-to-normal vision not using glasses
  • Not colour blind
  • Right-handed
  • Free from ferromagnetic objects in body
  • No history of any neurologic or psychiatric illness including drug abuse
  • No history of diabetes nor hypertension

    • No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
    • No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
  • No use of psychotropic drugs
  • Not studying or working in medicine, psychology, nor behavioural science
  • Not suffering from severe seasonal allergy
  • No use of cortisone, anti-histamines, nor any other immune-modulating drugs
  • Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine
  • No daily use of nicotine

Exclusion Criteria:

-

  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT02000076

Contacts
Contact: Gustav Nilsonne, MD, PhD +46736798743 gustav.nilsonne@ki.se
Contact: Mats Lekander, PhD +46852482445 mats.lekander@ki.se

Locations
Sweden
Karolinska Institutet, Karolinska Universitetssjukhuset i Solna Recruiting
Stockholm, None/Not Applicable, Sweden, SE-17177
Sponsors and Collaborators
Mats Lekander
Stockholm University
Investigators
Study Chair: Torbjörn Åkerstedt, PhD Stockholm University
Principal Investigator: Mats Lekander, PhD Stockholm University, Karolinska Institutet
Principal Investigator: Håkan Fischer, PhD Stockholm University
  More Information

No publications provided

Responsible Party: Mats Lekander, Professor, Karolinska Institutet
ClinicalTrials.gov Identifier: NCT02000076     History of Changes
Other Study ID Numbers: Sleepy Brain Study Wave 1
Study First Received: August 13, 2013
Last Updated: November 26, 2013
Health Authority: Sweden: Regional Ethical Review Board of Stockholm

Keywords provided by Karolinska Institutet:
Sleep
resting state
functional connectivity
emotional contagion
empathy
emotional regulation

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders

ClinicalTrials.gov processed this record on April 17, 2014