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Trial record 1 of 56 for:    "Schwannoma"
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Assessment of Volumetric Growth Rates of Spinal Intradural Extramedullary Schwannoma

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Chang-Hyun Lee, Seoul National University Hospital
ClinicalTrials.gov Identifier:
NCT01951365
First received: September 15, 2013
Last updated: September 23, 2013
Last verified: September 2013
  Purpose

Spinal intradural schwannoma detected incidentally increased recently. Because there is little knowledge about natural history of spinal schwannoma, there is no consensus of treatment. Our hypothesis is as follows;

  1. Some schwannomas keep growing, the others do not.
  2. Foraminal schwannomas do not usually grow.

The investigators analyzed natural history and characteristics of 56 spinal schwannomas observed initially with accurate and reliable methods. Here the investigators displayed growing pattern and differential point of spinal schwannoma.


Condition
Schwannoma
Neurinoma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Assessment of Volumetric Growth Rates of Spinal Intradural Extramedullary Schwannoma: A Longitudinal Study of Natural History

Resource links provided by NLM:


Further study details as provided by Seoul National University Hospital:

Primary Outcome Measures:
  • Volumetric growth rate [ Time Frame: 12, 24, 36, 48, 72, 96,120,144 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   None Retained

The investigators analyzed MR images only


Enrollment: 56
Study Start Date: June 1998
Study Completion Date: August 2013
Primary Completion Date: February 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Growing schwannoma
Overall volumetric growth rate more over than 10%
Stable schwannoma
Overall volumetric growth rate less than 10%

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

All patients diagnosed of spinal IDEM schwannoma in 2 institutes

Criteria

Inclusion Criteria:

  • All patients who were diagnosed of spinal IDEM schwannoma by MR imaging and checked follow-up MR imaging not undergoing surgical resection (including radiosurgery).

Exclusion Criteria:

  • 1) surgical resection at the diagnosis; 2) von Recklinghausen' disease (neurofibromatosis); and 3) recurred or residual tumor.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01951365

Locations
Korea, Republic of
Seoul National University Bundang Hospital
Seongnam, Kyenggi, Korea, Republic of, 110-769
Seoul Natl. Univ. Hospital
Seoul, Korea, Republic of, 110-769
Sponsors and Collaborators
Seoul National University Hospital
Investigators
Principal Investigator: Chang-Hyun Lee, MD Seoul Natl. Univ. Bundang Hospital
Study Chair: Chun Kee Chung, MD, PhD Seoul National University Hospital
  More Information

No publications provided

Responsible Party: Chang-Hyun Lee, Clinical Professor, Seoul National University Hospital
ClinicalTrials.gov Identifier: NCT01951365     History of Changes
Other Study ID Numbers: SNUNS-spine-01
Study First Received: September 15, 2013
Last Updated: September 23, 2013
Health Authority: Korea: Institutional Review Board

Keywords provided by Seoul National University Hospital:
Schwannoma
Growth
intradural
natural history

Additional relevant MeSH terms:
Neurilemmoma
Neoplasms
Neoplasms by Histologic Type
Neoplasms, Germ Cell and Embryonal
Neoplasms, Nerve Tissue
Nerve Sheath Neoplasms
Neuroectodermal Tumors
Neuroendocrine Tumors
Neuroma

ClinicalTrials.gov processed this record on November 20, 2014