Trial record 5 of 18 for:    "Hashimotos syndrome"

Fetuin A in Hashimoto Thyroiditis

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Sevilay Muratli, Istanbul Medeniyet University
ClinicalTrials.gov Identifier:
NCT01884649
First received: June 17, 2013
Last updated: June 21, 2013
Last verified: June 2013
  Purpose

Fetuin-A levels are reported to be low as a negative acute phase reactant in systemical inflammatory situations. Hashimoto thyroiditis is characterized with inflammation. In this study, we hypothesised that the serum fetuin A levels could be found to be low due to inflammation in patients with Hashimoto thyroiditis


Condition
Hashimoto Thyroiditis

Study Type: Observational [Patient Registry]
Study Design: Time Perspective: Cross-Sectional
Target Follow-Up Duration: 1 Day
Official Title: Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis

Resource links provided by NLM:


Further study details as provided by Istanbul Medeniyet University:

Primary Outcome Measures:
  • Comparison of serum fetuin A levels between patients with Hashimoto thyroiditis and healthy subjects [ Time Frame: 1 day (The blood samples were obtained on the same day participants arrived to outpatient clinics.) ] [ Designated as safety issue: No ]

Enrollment: 97
Study Start Date: May 2012
Study Completion Date: October 2012
Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
Group of Hashimoto thyroiditis patients
Healty control group

Detailed Description:

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the eligibility criteria will be included in the study. Approval of the local ethics committee and informed consent of the participants will be received for the study. The study is conducted in accordance with the Declaration of Helsinki. Demographic characteristics, concomitant diseases, smoking and alcohol drinking habits, concomitant medication usage, anthropometric and biochemistry data of the eligible patients will be recorded. Patient group will consist of patients with newly diagnosed Hashimoto thyroiditis and the control group will consist of healthy volunteers.

Groups will be compared according to their demographic, an¬thropometric and biochemistry data and serum fetuin-A levels. In order to detect the relationship between the serum fetuin-A levels and clinical features, correlation analyses will be done.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients ≥ 20 years of age being followed up at the outpatient clinics of the Internal Medicine Department in Medeniyet University Goztepe Training and Research Hospital and fulfilling the below mentioned criteria were included in the study

Criteria

Inclusion Criteria:

  • patients newly diagnosed with Hashimoto thyroiditis

Exclusion Criteria:

  • Acute infection
  • Acute or chronic inflammatory disease
  • Anti-inflammatory treatment (non-steroidal anti-inflammatory, corticosteroids etc.)
  • Hypoxic situations (chronic obstructive pulmonary disease etc.)
  • Severe heart, kidney and liver disease
  • Pregnancy
  • Endocrine disorders
  • Malignancy
  • Usage of drug that affects thyroid hormone levels
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Sevilay Muratli, M.D., Istanbul Medeniyet University
ClinicalTrials.gov Identifier: NCT01884649     History of Changes
Other Study ID Numbers: GEAH-1
Study First Received: June 17, 2013
Last Updated: June 21, 2013
Health Authority: Turkey: Ethics Committee

Keywords provided by Istanbul Medeniyet University:
Acute phase reactant, fetuin A, Hashimoto thyroiditis

Additional relevant MeSH terms:
Thyroiditis
Hashimoto Disease
Thyroid Diseases
Endocrine System Diseases
Thyroiditis, Autoimmune

ClinicalTrials.gov processed this record on August 18, 2014