Exploration of the Social Cognition in Adolescents With a Dissociative Disorder or Autism Spectrum
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Purpose
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
| Condition | Intervention |
|---|---|
|
Schizophrenia Autistic Disorder |
Other: Facial recognition of emotions Other: understanding metaphors Other: Attribution of intentionality to others in social situations depending on the type of situation |
| Study Type: | Interventional |
| Study Design: | Allocation: Non-Randomized Intervention Model: Parallel Assignment Masking: Open Label |
| Official Title: | EXPLORATION OF THE SOCIAL COGNITION IN ADOLESCENTS WITH A Dissociative Disorder OR AUTISM SPECTRUM |
- Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition [ Time Frame: First day ] [ Designated as safety issue: No ]
Compare cognitive profiles in clinical adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: the perception of emotions, attribution of intentions to others (theory of mind) and style attribution.
We will study the brain evoked potentials during the execution of the task of facial emotion recognition.
- Compare the cognitive profiles within the clinical group of schizophrenic [ Time Frame: First day ] [ Designated as safety issue: No ]
Compare the cognitive profiles within the clinical group of schizophrenic patients, depending on the type of schizophrenia presented (as positive, negative or disorganized).
For the study of attribution of intentions to others: This is to test the understanding of metaphors patients. Three types of statements are presented: forward literals, metaphorical statements and statements incongruous; patients should judge the plausibility semantics of these sentences. We study the behavioral and electrophysiological data.
- Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients. [ Time Frame: First day ] [ Designated as safety issue: No ]
Cognitive profiles compare clinical results between the different types of schizophrenia and autism patients.
Self-assessment in the form of a questionnaire with several social situations of everyday life. The subject must plan and assign intentionality to a character. We get scores dimensions studied.
| Estimated Enrollment: | 60 |
| Study Start Date: | January 2013 |
| Estimated Study Completion Date: | September 2013 |
| Primary Completion Date: | February 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: schizophrenia
child with a DSM-IV diagnosis of schizophrenia
|
Other: Facial recognition of emotions
The purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects.
Other: understanding metaphors
Explore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind).
Other: Attribution of intentionality to others in social situations depending on the type of situation
Compare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy.
|
|
Experimental: autism spectrum disorder
child with a DSM-IV diagnosis of autism spectrum disorder
|
Other: Facial recognition of emotions
The purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects.
Other: understanding metaphors
Explore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind).
Other: Attribution of intentionality to others in social situations depending on the type of situation
Compare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy.
|
|
Experimental: Healthy
child having no DSM-IV diagnosis of schizophrenia spectrum disorder or autism
|
Other: Facial recognition of emotions
The purpose is to consider the recognition of emotions expressed on face in patients with a schizophrenic disorder, autism and in healthy subjects.
Other: understanding metaphors
Explore understanding of figurative language, including metaphor, in schizophrenic patients, autistic and healthy, and well understand how patients develop an interpretation from access to speaker's communicative intentionality (theory mind).
Other: Attribution of intentionality to others in social situations depending on the type of situation
Compare the style of attribution of intentions in three populations of subjects: schizophrenic, autistic and healthy.
|
Detailed Description:
The schizophrenic disorders and pervasive developmental disorders are neurodevelopmental disorders distinct origin who share common challenges to engage and maintain social relationships and mutual disturbances of affective contact. An important issue of research is to determine the cognitive and brain mechanisms underlying social disability in these two pathologies. Several lines of social cognition have been systematically explored: the perception of emotions, the ability to attribute intentionality and mental states to others (theory of mind), the understanding of social situations in different contexts. We made the observation today that research findings clearly in the field of autism and schizophrenic disorders that converge on common patterns neurocognitive abnormalities. Consequently, many programs support published today use the same therapeutic targets and the same tools in both pathologies. This raises two questions of science: (1) whether the disorders of social cognition reported in the field of autism and schizophrenia are "specific deficit" and not "specific condition", that is to say they are inherent social disadvantage whatever condition or (2) if these disorders of social cognition is a pattern common to autism and schizophrenia but are the result of specific neurocognitive mechanisms and different in each these pathologies. Systematic exploration of these issues is a current issue for understanding the pathophysiological borders between the two neurodevelopmental disorders but also to better define the potential targets of therapeutic strategies, psycho-educational and remediation of disorders of social cognition in autism and schizophrenia.
Main objective: To compare clinical cognitive profiles in adolescents with a schizophrenic disorder, autistic or healthy in the three areas of social cognition: perception of emotions, attribution of intentions to others (theory of mind) and style attribution. We shall constitute three population groups of patients, a group of patients meeting the diagnosis of schizophrenia, a group of patients with autism and a control group (healthy subjects).
Inclusion criteria: patients aged 12 to 18, with a verbal IQ greater than or equal to 70, a DSM-IV diagnosis of autism and / or schizophrenia.
Assessment instruments: (1) clinical assessment instruments using standardized structured interviews that have already shown good sensitivity in our preliminary studies (2) techniques neuro-social cognition scientifically validated by the expert group of the ANR we are partners.
The study of active files and preliminary results, we can estimate the population to 20 patients per group, a total of 60 patients.
The originality of this study focuses on the ability to compare two populations in the same field of social cognition in three dimensions, which hitherto have been explored separately in the literature. The expected results are a range of prevention and treatment of major psychiatric children and adolescents because they help define therapeutic targets specific to each population
Eligibility| Ages Eligible for Study: | 12 Years to 18 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Child with a DSM-IV diagnosis of schizophrenia or autism spectrum disorder:
- Schizophrenic patients, positive to the award of psychosis section of the Kiddie SADS and having a negative ADI.
or:
Patients with autism spectrum disorder, diagnosed by the scale ADI (Autism Diagnostic Interview) or ADOS (Autism Diagnostic Observation Schedule): Autism Asperger and PDD nos. These patients do not respond to a diagnosis of psychosis Kiddie-SADS according.
- Total IQ greater than or equal to 70
Exclusion Criteria:
- Genetic disorders, neurological and neurosensory
- Child satisfy both the diagnosis of autism spectrum disorder and schizophrenia than (comorbidity).
- Will not be included patients who participate in a study on rehabilitation for social skills.
Contacts and Locations| Contact: Emmanuelle DOR, Medical Doctor | dor.nedonsel@lenval.com | |
| Contact: Cassandre LANDES, engineer | 0492034126 ext +33 | landes.c@chu-nice.fr |
| France | |
| Centre Hospitalier d'Antibes Juans les Pins | Active, not recruiting |
| Antibes, France, 06600 | |
| Centre hospitalier de Cannes | Active, not recruiting |
| Cannes, France, 06400 | |
| CHU de Nice | Recruiting |
| Nice, France, 06000 | |
| Contact: Emmanuelle DOR, Medical doctor dor.nedonsel@lenval.com | |
| Contact: Valérie BONNARD-COUTON, medical student val434@hotmail.com | |
| Sub-Investigator: Eva LE GALL, psychologist | |
| Principal Investigator: Emmanuelle DOR, Medical Doctor | |
| Sub-Investigator: Florence ASKENAZY, Medical Doctor | |
| Principal Investigator: | Emmanuelle DOR, Medical Doctor | CHU de Nice |
More Information
No publications provided
| Responsible Party: | Centre Hospitalier Universitaire de Nice |
| ClinicalTrials.gov Identifier: | NCT01805128 History of Changes |
| Other Study ID Numbers: | 12-AOI-04 |
| Study First Received: | February 22, 2013 |
| Last Updated: | March 4, 2013 |
| Health Authority: | France: Committee for the Protection of Personnes |
Keywords provided by Centre Hospitalier Universitaire de Nice:
|
Schizophrenia Autistic Disorder social cognition |
Additional relevant MeSH terms:
|
Autistic Disorder Dissociative Disorders Conversion Disorder Schizophrenia Child Development Disorders, Pervasive |
Mental Disorders Diagnosed in Childhood Mental Disorders Somatoform Disorders Schizophrenia and Disorders with Psychotic Features |
ClinicalTrials.gov processed this record on May 22, 2013