Branched Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College Females
The purpose of this study is to determine if a dietary supplement containing branched chain amino acids will reduce the muscle soreness that sometimes occurs in the days following exercise.
Exercise-induced Delayed Onset Muscle Soreness
Dietary Supplement: Branched Chain Amino Acid drink supplement
Dietary Supplement: Placebo
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Supportive Care
|Official Title:||The Effects of Branched Chain Amino Acid and Nutrient Supplementation on Exercise-Induced Delayed Onset Muscle Soreness in College Females|
- Delayed Onset Muscle Soreness Rating Scale [ Time Frame: Every 24 hours for four days following exercise ] [ Designated as safety issue: No ]
|Study Start Date:||September 2011|
|Primary Completion Date:||November 2012 (Final data collection date for primary outcome measure)|
Experimental: Branch Chain Amino Acid supplement
A drink supplement containing 1.22 grams of branched chain amino acids, plus glucose.
|Dietary Supplement: Branched Chain Amino Acid drink supplement|
Placebo Comparator: Placebo supplement
The placebo was formulated to match both the taste and color of the test supplement. Crystal Light Lemonade powder (Kraft Foods, Northfield, IL, USA) was mixed with 5.6g of powdered dextrose (Now Foods, Bloomingdale, IL, USA) to match the amount of dextrose present in the BCAA supplement.
|Dietary Supplement: Placebo|
Supplementation with branched chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA (n=10) or placebo (n=10) groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (p = 0.018). No significant effect of BCAA supplementation versus placebo was noted in male subjects, nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01781910
|United States, Vermont|
|University of Vermont|
|Burlington, Vermont, United States, 05405|
|Principal Investigator:||Stephen J Pintauro, Ph.D.||University of Vermont|