Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2013 by Lund University
Sponsor:
Information provided by (Responsible Party):
Bo Ahren, Lund University
ClinicalTrials.gov Identifier:
NCT01779622
First received: January 27, 2013
Last updated: December 19, 2013
Last verified: December 2013
  Purpose

To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers


Condition Intervention
Healthy Volunteers Recruited From the General Population
Other: Mixed meal

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin

Resource links provided by NLM:


Further study details as provided by Lund University:

Primary Outcome Measures:
  • Area under the curve for insulin [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Area under the curve for glucose-dependent insuinotropic polypeptide [ Time Frame: 300 min ] [ Designated as safety issue: No ]
  • Area under the curve for glucagon-like peptide-1 [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Other Outcome Measures:
  • Area under the curve for glucagon [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Estimated Enrollment: 24
Study Start Date: June 2013
Estimated Study Completion Date: June 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Healthy volunteers are ingesting a mixed meal either rapidly or slowly
Other: Mixed meal
Ingestion of mixed meal

Detailed Description:

A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects

Exclusion Criteria:

  • Diabetes Liver disease Kidney disease Thyroid disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01779622

Locations
Sweden
Department of Clinical Sciences, Lund University Recruiting
Lund, Sweden, 22184
Contact: Bo Ahrén    46462220758    Bo.Ahren@med.lu.se   
Principal Investigator: Bo Ahrén         
Sponsors and Collaborators
Lund University
  More Information

Additional Information:
No publications provided

Responsible Party: Bo Ahren, Professor, Lund University
ClinicalTrials.gov Identifier: NCT01779622     History of Changes
Other Study ID Numbers: 17, 2013-000449-38
Study First Received: January 27, 2013
Last Updated: December 19, 2013
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Lund University:
mixed meal¨
insulin
glucagon
GIP
GLP-1

Additional relevant MeSH terms:
Incretins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on July 24, 2014