Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin Hormone Secretion in Healthy Volunteers

This study is currently recruiting participants.
Verified December 2013 by Lund University
Sponsor:
Information provided by (Responsible Party):
Bo Ahren, Lund University
ClinicalTrials.gov Identifier:
NCT01779622
First received: January 27, 2013
Last updated: December 19, 2013
Last verified: December 2013
  Purpose

To test the influence of rapid versus slow ingestion of a mixed meal on insulin and incretin hormone secretion in healthy volunteers


Condition Intervention
Healthy Volunteers Recruited From the General Population
Other: Mixed meal

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Rapid Versus Slow Ingestion of Mixed Meal: Influence on Islet and Incretin

Resource links provided by NLM:


Further study details as provided by Lund University:

Primary Outcome Measures:
  • Area under the curve for insulin [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Area under the curve for glucose-dependent insuinotropic polypeptide [ Time Frame: 300 min ] [ Designated as safety issue: No ]
  • Area under the curve for glucagon-like peptide-1 [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Other Outcome Measures:
  • Area under the curve for glucagon [ Time Frame: 300 min ] [ Designated as safety issue: No ]

Estimated Enrollment: 24
Study Start Date: June 2013
Estimated Study Completion Date: June 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1
Healthy volunteers are ingesting a mixed meal either rapidly or slowly
Other: Mixed meal
Ingestion of mixed meal

Detailed Description:

A mixed meal (524 kcal) is ingested rapidly (within 5 min) or slowly (10-15 min) and changes in insulin, glucagon, GIP and GLP-1 levels are followed for subsequent 300 min

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects

Exclusion Criteria:

  • Diabetes Liver disease Kidney disease Thyroid disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01779622

Locations
Sweden
Department of Clinical Sciences, Lund University Recruiting
Lund, Sweden, 22184
Contact: Bo Ahrén    46462220758    Bo.Ahren@med.lu.se   
Principal Investigator: Bo Ahrén         
Sponsors and Collaborators
Lund University
  More Information

Additional Information:
No publications provided

Responsible Party: Bo Ahren, Professor, Lund University
ClinicalTrials.gov Identifier: NCT01779622     History of Changes
Other Study ID Numbers: 17, 2013-000449-38
Study First Received: January 27, 2013
Last Updated: December 19, 2013
Health Authority: Sweden: Regional Ethical Review Board

Keywords provided by Lund University:
mixed meal¨
insulin
glucagon
GIP
GLP-1

Additional relevant MeSH terms:
Incretins
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Pharmacologic Actions

ClinicalTrials.gov processed this record on April 17, 2014