Long-term Control in Rhinosinusitis After ESS
State-of-the-art documents like ARIA and EP3OS provide clinicians with evidence-based treatment algorithms for allergic rhinitis (AR) and chronic rhinosinusitis (CRS) respectively (1)(2) . The currently available medications can alleviate symptoms associated with AR and RS, and most patients with RS benefit from endoscopic sinus surgery (ESS). In real life, a significant percentage of patients with AR and CRS continue to experience bothersome symptoms despite adequate treatment. This group with so-called severe chronic upper airway disease (SCUAD) represents a therapeutic challenge (3).
Condition of Patient 3 Years After FESS-operation
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Long-term Control in Rhinosinusitis After ESS: Cross-sectional Observational Study on Control in Rhinosinusitis at a Mean Interval of 3 Years After ESS|
- Control status of patients with rhinosinusitis + symptoms analysis [ Time Frame: 3 years after FESS ] [ Designated as safety issue: No ]
- Percentage of patients with rhinosinusitis that are fully controlled, partly controlled and uncontrolled according to the new EPOS definitions at a mean interval of 3 years after endoscopic sinus surgery.
- Correlation between the new definition of control and the SNOT-22 questionnaire and VAS scores for total and individual sino-nasal symptoms
- factor analysis and clinical examination [ Time Frame: 3 years after FESS ] [ Designated as safety issue: No ]Subgroup analysis with delineation of different factors associated with the degree of control in rhinosinusitis: age, gender, allergy, smoking, occupation, anatomic factors, asthma, COPD, aspirin intolerance, current medication use, CF, PCD, known immune deficiency.
- degree of control of symptoms [ Time Frame: 3 years after ESS ] [ Designated as safety issue: No ]Doctors' evaluation of the reason for degree of control of symptoms: disease-related (SCUAD), diagnosis-related, treatment-related, or patient related reasons for lack of control.
- control nasal endoscopy [ Time Frame: 3 years after ESS ] [ Designated as safety issue: No ]Evaluating of difference in control if nasal endoscopy is performed three years after ESS.
|Study Start Date:||December 2012|
|Study Completion Date:||May 2013|
|Primary Completion Date:||May 2013 (Final data collection date for primary outcome measure)|
patients having undergone endoscopic sinus surgery (ESS) for bilateral inflammatory sinonasal disease from January 2008 until December 2010.
control group of 200 patients attending the general ENT Outpatient clinic
|UZ Leuven ORL|
|Leuven, Vlaams Brabant, Belgium, 3000|
|Leuven, Vlaams-Brabant, Belgium, 3000|
|Principal Investigator:||Peter Hellings, MD||UZ Leuven|