The Role of Uterine Artery Doppler Parameters in the Management of Retained Products of Conception.

This study is currently recruiting participants. (see Contacts and Locations)
Verified June 2014 by Carmel Medical Center
Sponsor:
Information provided by (Responsible Party):
Carmel Medical Center
ClinicalTrials.gov Identifier:
NCT01775917
First received: January 23, 2013
Last updated: June 1, 2014
Last verified: June 2014
  Purpose

During the recent decades the need for surgical evacuation of the uterus in early miscarriages and incomplete miscarriages has been questioned.

It has been shown that an observational approach can be, in many cases, as good as an invasive one without increasing the incidence of uterine infections.

it has been shown that misoprostol - prostaglandin E1 given for missed abortions is successful in emptying the uterus in 85% of cases without any need for surgical intervention. and during recent years many women prefer this approach than the surgical one .

Many have tried using sonographic signs such as endometrial thickness, the presence of a gestational sac, and color doppler to differ between blood clots and a gestational residua in uterus, and to decide according to these signs wether there is a need for surgical evacuation or an expectant management could be used. but none of these methods have been proven to be completely efficient as predictors.

In this study the investigators will examine whether the doppler indices in the uterine arteries can help to predict which gestational residua needs surgical evacuation of the uterus and which could be managed expectantly.

The study hypothesis is that the resistance in uterine artery doppler will be lower in cases with intrauterine residua as opposed to high resistance in cases without residua.


Condition
Missed Abortion
Incomplete Abortion
Uterine Gestational Residua
Uterine Artery Doppler

Study Type: Observational [Patient Registry]
Study Design: Time Perspective: Prospective
Target Follow-Up Duration: 6 Weeks
Official Title: The Role of Uterine Artery Doppler Parameters in the Management of Retained Products of Conception.

Further study details as provided by Carmel Medical Center:

Primary Outcome Measures:
  • uterine artery doppler parameters [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    comparison between uterine artery doppler parameters after complete abortion with misoprostol to doppler parameters in incomplete abortion with the need of surgical uterine evacuation. and in result to try and find a doppler value that could be used to predict the success of observational management in incomplete abortions or abortions with misoprostol.


Secondary Outcome Measures:
  • success rate of treatment of misoprostol in missed and incomplete abortions [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Estimated Enrollment: 200
Study Start Date: January 2013
Estimated Study Completion Date: January 2015
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
Detailed Description:

It's a prospective observational study that will take place in the gynecology department in Carmel medical center in Haifa, Israel.

The study population are women with the diagnosis of missed abortion matching 8 weeks of pregnancy or less, incomplete abortion or anembryonic pregnancy that are treated with misoprostol in the gynecologic emergency room according to the department's protocol.

our department's protocol for the treatment of missed abortion matching 8 weeks of pregnancy or less, anembryonic pregnancy or incomplete abortions . these women usually get a full explanation from the doctor in the emergency room about the possible treatments :

  1. surgical evacuation i.e. dilatation and curettage
  2. treatment with misoprostol 800 mcg given vaginally. both treatments are used routinely in our emergency room. If the woman chooses the treatment with misoprostol she will then also be told about the study and if she agrees to participate in the study she will sign an informed consent form.

After getting the first dose of misoprostol 800 mcg vaginally the woman is usually discharged home and then a sonographic follow up will be done on several preset occasions where an ultrasound is done vaginally and few sonographic indices are examined : the presence of gestational sac or gestational residua and its size, color doppler for the residua, the size of uterus... in addition to these indices routinely examined during the follow up according to the department protocol we will examine in this study the indices of uterine artery doppler (i.e. S/D ratio, resistance index, pulsatility index).

according to the department protocol day 3 will be the first day of follow up , if a gestational sac is still seen in the uterus, or an endometrial thickness above 30 mm, a second dose of misoprostol is given, and the women will be reexamined on day 10, then a surgical evacuation is performed if we still have the same findings (gestational sac or endometrium >30mm) otherwise the woman is discharged and the last follow up will be on day 4-5 of her next menstruation, that's when it will be decided if the abortion is complete and the uterus is completely empty. if a gestational residua is found after the menstruation then the woman will have to go through surgical evacuation .

In the end we will compare the uterine artery doppler indices of the women with complete abortions to those with failed misoprostol treatment who needed surgical evacuation .

No change in the treatment will be done during the study based on the uterine artery doppler indices , it's only an observational study .

  Eligibility

Ages Eligible for Study:   20 Years to 45 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

women of age 20-45 with missed abortion up to 8 weeks of pregnancy or incomplete abortion treated with misoprostol in the emergency room

Criteria

Inclusion Criteria:1. women with missed abortion (embryo karger than 5 mm with no heart beat) or anembryonic pregnancy (empty gestational sac larger than 20 mm) 2. incomplete abortion 3. missed abortion with CRL (crown ump length) no larger than 8 weeks of pregnancy 4. women who got a clear explanation about all treatment options and they chose misoprostol as a treatment 5. women who read and signed an informed consent form

Exclusion Criteria:

  1. known allergy to prostaglandins or NSAIDS
  2. heavy vaginal bleeding and hemodynamic instability
  3. multifetal gestation
  4. women with a clotting problems or treated with anticoagulant medications
  5. fever above 37.5 c
  6. anemia with hemoglobin < 9/5 gr%
  7. missed abortion with CRL larger than 8 weeks of pregnancy
  8. diseases that can be aggravated by prostaglandins : severe asthma, uncontrolled blood pressure, glaucoma, sickle cell anemia, mitral stenosis
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01775917

Contacts
Contact: grace younes, MD 972508845924 graceyounes@gmail.com

Locations
Israel
Carmel Medical Center Recruiting
Haifa, Israel
Sponsors and Collaborators
Carmel Medical Center
Investigators
Principal Investigator: Grace Younes, M.D Carmel Medical Center
  More Information

No publications provided

Responsible Party: Carmel Medical Center
ClinicalTrials.gov Identifier: NCT01775917     History of Changes
Other Study ID Numbers: CMC-12-0106-CTIL
Study First Received: January 23, 2013
Last Updated: June 1, 2014
Health Authority: Israel: Ethics Commission

Additional relevant MeSH terms:
Abortion, Incomplete
Abortion, Missed
Abortion, Spontaneous
Pregnancy Complications

ClinicalTrials.gov processed this record on August 19, 2014