Diffusion MRI and Growth Plate Injuries: Pilot Study
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Purpose
Children who suffer fractures to the growth plates (physes) of their bones are at risk for premature growth arrest which can lead to long term complications. There is currently no technique to predict who is at risk of growth arrest following a physeal injury. The investigators aim to determine if diffusion MRI (an imaging method to analyze tissue properties) can effectively pick up differences between a healthy growth plate and an injured one. This would allow orthopaedics surgeons to predict which injuries are at a higher risk of growth arrest, so earlier interventions can be done in the orthopaedic clinic.
| Condition | Intervention |
|---|---|
|
Fracture |
Other: Diffusion MRI |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Diffusion MRI as a Prognostic Tool in Growth Plate Injuries: A Pilot Study to Assess Feasibility |
- Tissue characterization of growth plate using diffusion MRI [ Time Frame: 4-6 weeks following injury ] [ Designated as safety issue: No ]Diffusion MRI scan of injured and contralateral (control) physis.
| Estimated Enrollment: | 10 |
| Study Start Date: | November 2013 |
| Estimated Study Completion Date: | June 2014 |
| Estimated Primary Completion Date: | January 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Physeal Injury - Distal Radius
Patients who suffer a physeal fracture of the distal radius will be scanned and compared to their healthy contralateral limb.
|
Other: Diffusion MRI
Each subject will undergo one diffusion MRI scan to identify characteristics of their physes
|
Detailed Description:
The purpose of this study is to determine if diffusion MRI can be used for tissue characterization in childhood and adolescent growth plate injuries, and to get a better understanding of the physiologic disturbance of an injured physis
Eligibility| Ages Eligible for Study: | 8 Years to 12 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Study subjects will be selected from the Orthopaedic Trauma Clinic at BC Children's Hospital
Inclusion Criteria:
- Salter-Harris Type II, III, or IV fracture through the distal radius
- Growth plates are open
- Ages 8-12
- Able to consent in English
Exclusion Criteria:
- All fractures not sustained to distal radius
- SH Type I or V fracture
- Injury to contralateral limb
- Previous injury to distal radius
- Diseases known to alter bone healing or growth]
- Contraindications to undergoing an MRI scan
Contacts and Locations| Contact: Michael Nitikman | 604-875-2359 | michael.nitikman@cw.bc.ca |
| Contact: Jill Kennedy | 604-875-3259 | jill.kennedy@cw.bc.ca |
| Canada, British Columbia | |
| British Columbia Children's Hospital | Not yet recruiting |
| Vancouver, British Columbia, Canada, V6H 3V4 | |
| Contact: Jill Kennedy 604-875-2359 jill.kennedy@cw.bc.ca | |
| Principal Investigator: Firoz Miyanji, MD, FRCSC | |
| Sub-Investigator: Kishore Mulpuri, MBBS, MS, MHSc | |
| Sub-Investigator: Chris Reilly, MD, FRCSC | |
| Sub-Investigator: Ken Poskitt, MDCM | |
| Principal Investigator: | Firoz Miyanji, MD, FRCSC | University of British Columbia |
More Information
No publications provided
| Responsible Party: | University of British Columbia |
| ClinicalTrials.gov Identifier: | NCT01774539 History of Changes |
| Other Study ID Numbers: | H12-03016 |
| Study First Received: | January 22, 2013 |
| Last Updated: | January 22, 2013 |
| Health Authority: | Canada: Health Canada |
Keywords provided by University of British Columbia:
|
Fracture Physeal injury Diffusion MRI |
Additional relevant MeSH terms:
|
Fractures, Bone Wounds and Injuries |
ClinicalTrials.gov processed this record on June 18, 2013