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Neurophysiological Molecular and Developmental Analysis of the Glutamate Synapse in Autism (NMDA-Autism)

This study is currently recruiting participants.
Verified January 2013 by University Hospital, Tours
Sponsor:
Information provided by (Responsible Party):
University Hospital, Tours
ClinicalTrials.gov Identifier:
NCT01770548
First received: January 15, 2013
Last updated: January 16, 2013
Last verified: January 2013
History of Changes
  Purpose

Neurophysiological, Molecular and Developmental Analysis of the glutamate synapse in Autism


Condition Intervention
Autism
 Genetic: analysis of the glutamate synapse in autism
Genetic: DNA collection
Other: Auditory evoked potentials

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Official Title: Autism and Glutamatergic Synapse : Research of Genetic Mutations and Identification of Clinical and Neurophysiological Markers.

Resource links provided by NLM:

MedlinePlus related topics: Autism
U.S. FDA Resources

Further study details as provided by University Hospital, Tours:

Primary Outcome Measures:
  • screening of about 50 genes encoding proteins of the NMDA receptor complex, chosen according to their chromosomal localisation located in hotspots depicted by genome-wide screens in large population of autistic patients [ Time Frame: two years ] [ Designated as safety issue: No ]

Estimated Enrollment: 600
Study Start Date: January 2009
Estimated Study Completion Date: July 2013
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Autism
Analysis of the glutamate synapse in autism
 Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Relative
Analysis of the glutamate synapse in autism
 Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Major control
DNA collection
 Genetic: analysis of the glutamate synapse in autism
Neurophysiological, molecular and developmental analysis of the glutamate synapse in autism
Genetic: DNA collection
DNA collection
Other: Auditory evoked potentials
auditory evoked potentials
Minor control
auditory evoked potentials
 Other: Auditory evoked potentials
auditory evoked potentials

Detailed Description:

Analysis about 50 genes in glutamate synapse

  Eligibility

Ages Eligible for Study:   2 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • have a Pervasive Developmental Disorder

Exclusion Criteria:

  • N/A
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01770548

Contacts
Contact: Frédérique BONNET-BRILHAULT, Dr +33(0)2 34 38 94 35 f.bonnet-brilhault@chu-tours.fr

Locations
France
CHRU - Centre de Ressources Autisme (CRA) Recruiting
Brest, France, 29000
Contact: Eric LEMONNIER, Dr     +33 (2) 98 01 52 06     eric.lemonnier@chu-brest.fr    
Contact: Eric LEMONNIER     +33 (2) 98 01 52 06     eric.lemonnier@chu-brest.fr    
Principal Investigator: Eric LEMONNIER, Dr            
CHS du ROUVRAY Not yet recruiting
Rouen, France, 76000
Contact: Dominique CAMPION, Dr         dominique.campion@univ-rouen.fr    
CHRU - Pédopsychiatrie Recruiting
Tours, France, F-37000
Contact: Frédérique BONNET-BRILHAULT, Pr     +33(2)34389435     f.bonnet-brilhault@chu-tours.fr    
Principal Investigator: Frédérique BONNET-BRILHAULT, Dr            
Chru - Cic Recruiting
Tours, France, 37000
Contact: Valérie GISSOT, Dr     +33 (2)34379653     valerie.gissot@univ-tours.fr    
Principal Investigator: Valerie GISSOT, Dr            
Sponsors and Collaborators
University Hospital, Tours
  More Information

No publications provided

Responsible Party: University Hospital, Tours
ClinicalTrials.gov Identifier: NCT01770548     History of Changes
Other Study ID Numbers: AORT08-FBB/NMDA-Autism, 2008-A01162-53
Study First Received: January 15, 2013
Last Updated: January 16, 2013
Health Authority: France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Mental Disorders Diagnosed in Childhood
Mental Disorders

ClinicalTrials.gov processed this record on May 19, 2013