Carboplatin-Paclitaxel ± Bevacizumab in Advanced (Stage III-IV) or Recurrent Endometrial Cancer (MITOBEVAEND2)

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2012 by Catholic University of the Sacred Heart
Sponsor:
Information provided by (Responsible Party):
Prof. Giovanni Scambia, Catholic University of the Sacred Heart
ClinicalTrials.gov Identifier:
NCT01770171
First received: December 10, 2012
Last updated: January 15, 2013
Last verified: December 2012
  Purpose

Wright et al (Anticancer Res, 2000) reported the results of a retrospective study on 11 patients with advanced/recurrent endometrial cancers. All patients had multi-site disease and were heavily pretreated with a median of 3 prior chemotherapy regimens. All received bevacizumab combination therapy which was well-tolerated. Two patients had partial responses, 3 had stable disease, while 5 patients progressed. One subject was not assessable for response. The median progression-free interval was 5.4 months for the entire cohort and 8.7 months for those who achieved clinical benefit (PR or SD). The authors concluded that Bevacizumab was well-tolerated and displayed promising anti-neoplastic activity in patients with endometrial cancer.The rationale for combining anti-angiogenic agents, including anti-VEGF antibodies, with cytotoxic chemotherapy stems from a number of preclinical studies showing additive and synergistic anti-tumour activity in a number of solid tumour types. By combining VEGF-targeting agents such as bevacizumab with conventional chemotherapies, it is hoped that these agents will act synergistically, thereby enhancing their anti-tumour efficacy and controlling disease progression.

The addition of bevacizumab to chemotherapy has been shown to improve PFS and/or OS in a series of large, randomized Phase III clinical trials in a wide range of tumour types, including mCRC, non-squamous NSCLC, metastatic BC (mBC) and mRCC.


Condition Intervention Phase
Stage III-IV or Recurrent Endometrial Cancer
Drug: Bevacizumab
Drug: Carboplatin AUC 5+Paclitaxel 175 mg/mq q 21 for 6-8 cycles
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Randomized Phase II Trial of Carboplatin-Paclitaxel Compared to Carboplatin-Paclitaxel-Bevacizumab in Advanced (Stage III-IV) or Recurrent Endometrial Cancer

Resource links provided by NLM:


Further study details as provided by Catholic University of the Sacred Heart:

Primary Outcome Measures:
  • Progression-free survival [ Time Frame: 3 months ] [ Designated as safety issue: No ]
    • Progression-free survival, defined as the time from the date of randomization to the date of documented progressive disease, recurrence or death (whichever occurs first)


Secondary Outcome Measures:
  • Overall survival [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
    • Overall survival defined as the time from the date of randomization to the date of death

  • Best target lesion response [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    Best target lesion response, defined as best change in sum of the target lesions from baseline to disease progression.

  • Duartion of Response [ Time Frame: 3 months ] [ Designated as safety issue: Yes ]
    Duration of response Safety and tolerability

  • Quality of life [ Time Frame: 3 cycle ] [ Designated as safety issue: No ]
    Changes Quality of Life parameters as measured using EORTC QLQ-30 & EORTC-QLQ-EN-24


Estimated Enrollment: 108
Study Start Date: April 2012
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2017 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Carboplatin-paclitaxel-bevacizumab
Carboplatin AUC 5+ Paclitaxel 175 mg/mq+Bevacizumab 15 mg/kg q 21 for 6 -8 cycles + Bevacizumab 15 mg/kg every 3 weeks until disease progression
Drug: Bevacizumab
Carboplatin AUC 5+ Paclitaxel 175 mg/mq+Bevacizumab 15 mg/kg q 21 for 6 -8 cycles + Bevacizumab 15 mg/kg
Active Comparator: carboplatin-paclitaxel
Carboplatin AUC 5+Paclitaxel 175 mg/mq q 21 for 6-8 cycles
Drug: Carboplatin AUC 5+Paclitaxel 175 mg/mq q 21 for 6-8 cycles
Carboplatin AUC 5+Paclitaxel 175 mg/mq q 21 for 6-8 cycles

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  1. ≥18 years of age.
  2. ECOG Performance Status of 0-2.
  3. Life expectancy of at least 12 weeks.
  4. Patients must have advanced stage III or IV, or recurrent histologically-confirmed endometrial cancer.
  5. Endometrial cancer will include all carcinomas, including endometrioid carcinoma, papillary serous carcinoma, clear cell carcinoma.
  6. One previous chemotherapy lines is allowed if platinum free interval is more than six mounths (previous radiotherapy is allowed).

7 Measurable and not measurable disease. 8 Adequate renal and hepatic function, defined as:

  • Total serum bilirubin ≤ institutional ULN unless patient has Gilbert's syndrome in which case direct bilirubin must be < ULN for the institution.
  • AST and/or ALT ≤ 2.5 x ULN for the institution. (or ≤ 5 x ULN if liver metastases are present)
  • Alkaline phosphatase < 1.5 x ULN for the institution (if > 1.5 x ULN, then alkaline phosphatase liver fraction must be < 1.5 ULN).
  • Serum creatinine ≤ 1.5 x ULN for the institution (or calculated creatinine clearance ≥ 50 mL/min/1.73 m2) 9 Adequate bone marrow function, defined as:
  • Total leukocytes ³ 3.0 x 109/L.
  • ANC ³ 1.5 x 109/L.
  • Platelet count ³ 100 x 109/L. Able to understand and give written informed consent. 10 Females of childbearing potential must have a negative serum pregnancy test within 7 days prior to study enrollment.

Exclusion Criteria:

  1. Previous cytotoxic chemotherapy.
  2. Women who are pregnant or lactating.
  3. Presence of brain or other central nervous system metastases.
  4. Anticancer treatment within 4 weeks prior to randomization.
  5. Ongoing toxicity associated with prior anticancer therapy.
  6. Inadequate recovery from any prior surgical procedure or having undergone any major surgical procedure within 4 weeks prior to randomization. Patients who have recovered from placement of a central venous access port within 2 weeks of Cycle 1 Day 1 will be considered eligible.
  7. Another primary malignancy within the past five years (except for non-melanoma skin cancer and cervical carcinoma in situ).
  8. Current or recent (within 10 days prior to the first study drug dose) chronic daily treatment with aspirin (>325 mg/day).
  9. Current or recent (within 10 days prior to the first study drug dose) use of full-dose oral or parenteral anticoagulant or thrombolytic agent for therapeutic purposes.
  10. Inadequate coagulation parameters:activated partial thromboplastin time (APTT) >1.5 xULN or INR >1.5.
  11. Known HIV infection.
  12. Known hepatitis B or C infection.
  13. Concurrent treatment with immunosuppressive or investigational agents.
  14. History or evidence of thrombotic or hemorrhagic disorders; including cerebrovascular accident (CVA) / stroke or transient ischemic attack (TIA) or subarachnoid haemorrhage within _6 months prior to the first study treatment).
  15. Uncontrolled hypertension (sustained systolic >150 mm Hg and/or diastolic >100 mm Hg despite antihypertensive therapy) or clinically significant (i.e. active) cardiovascular disease, including.
  16. Myocardial infarction or unstable angina within _6 months prior to the first study treatment.
  17. New York Heart Association (NYHA) grade II or greater congestive heart failure (CHF).
  18. Serious cardiac arrhythmia requiring medication (with the exception of atrial fibrillation or paroxysmal supraventricular tachycardia).
  19. Peripheral vascular disease _grade 3 (i.e.symptomatic and interfering with activities of daily living requiring repair or revision).
  20. History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to the first study treatment.
  21. Non-healing wound, ulcer or bone fracture. Patients with granulating incisions healing by secondary intention with no evidence of facial dehiscence or infection are eligible but require three weekly wound examinations.
  22. Serious active infection requiring i.v. antibiotics at enrolment.
  23. Significant traumatic injury during the 4 weeks preceding the first dose of bevacizumab.
  24. Known hypersensitivity to any of the study drugs or excipients (including cremophor and hamster Ovary cell products).
  25. Evidence of any other medical conditions (such as psychiatric illness, peptic ulcer, etc.), physical examination or laboratory findings that may interfere with the planned treatment, affect patient compliance or place the patient at high risk from treatment related complications.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01770171

Contacts
Contact: Catholic University of Sacred Heart . +39 0630156279

Locations
Italy
Catholic University of Sacred Heart Rome, Recruiting
Rome,, Rome, Italy, 00100
Sponsors and Collaborators
Catholic University of the Sacred Heart
Investigators
Principal Investigator: Giovanni Scambia, Prof Catholic University of Sacred Heart
Principal Investigator: Domenica Lorusso, MD National Cancer Institute, Milan
  More Information

No publications provided

Responsible Party: Prof. Giovanni Scambia, Professor Giovanni Scambia, Catholic University of the Sacred Heart
ClinicalTrials.gov Identifier: NCT01770171     History of Changes
Other Study ID Numbers: MITOBEVAEND2
Study First Received: December 10, 2012
Last Updated: January 15, 2013
Health Authority: Italy: Ethics Committee

Keywords provided by Catholic University of the Sacred Heart:
endometrial cancer
recurrent endometrial cancer
bevacizumab

Additional relevant MeSH terms:
Endometrial Neoplasms
Uterine Neoplasms
Genital Neoplasms, Female
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Uterine Diseases
Genital Diseases, Female
Bevacizumab
Carboplatin
Paclitaxel
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Antineoplastic Agents, Phytogenic
Tubulin Modulators
Antimitotic Agents
Mitosis Modulators
Molecular Mechanisms of Pharmacological Action
Angiogenesis Inhibitors
Angiogenesis Modulating Agents
Growth Substances
Physiological Effects of Drugs
Growth Inhibitors

ClinicalTrials.gov processed this record on August 18, 2014