Variable Pressure Support Trial (ViPS)
In 2008 a new ventilation strategy termed variable Pressure Support ventilation (PSV) was introduced, which is able to increase the variability of the respiratory pattern independent from the inspiratory effort. In experimental lung injury, variable PSV was found to improve gas exchange and decrease the inspiratory effort, while reducing alveolar edema and inflammatory infiltration compared to conventional(non-variable) PSV. Importantly, variable PSV reduced peak airway pressure and respiratory system elastance in a variability dependent manner.In addition, preliminary observations suggest that variable PSV can reduce the work of breathing and improve patient comfort, but it is not known whether this new ventilatory strategy is able to speed the weaning from mechanical ventilation.
Since variable PSV can reduce the mean pressure support, it may lead to a faster reduction of pressure support and, therefore, a shorter weaning period than conventional PSV.
The hypothesis of this study is that variable pressure support ventilation reduces the duration of mechanical ventilation to non-variable (conventional) pressure support ventilation.
Acute Lung Injury
Adult Respiratory Distress Syndrome
at Least 24 h of Controlled Mechanical Ventilation
Other: Variable Ventilation
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||International Multicenter Randomized Controlled Open Trial on Variable vs. Non-Variable Pressure Support for Weaning From Mechanical Ventilation|
- Weaning time [ Time Frame: From time of randomization until the time of successful extubation, estimated to be up to 30 days ] [ Designated as safety issue: No ]Weaning time defined as time from randomization to successful extubation.
|Study Start Date:||January 2013|
|Estimated Study Completion Date:||January 2015|
|Estimated Primary Completion Date:||January 2015 (Final data collection date for primary outcome measure)|
Active Comparator: Variable Ventilation
Patients are ventilated with variable pressure support mode.
|Other: Variable Ventilation|
No Intervention: Conventional (non-variable) Ventilation
Patients are ventilated with non-variable(conventional) pressure support ventilation mode.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01769053
|Department of Anesthesiology and Intensive Care, Dresden University of Technology||Recruiting|
|Dresden, Germany, 01307|
|Contact: Thomas Kiss firstname.lastname@example.org|
|Contact: Marcelo Gama de Abreu email@example.com|
|Principal Investigator: Marcelo Gama de Abreu|
|Principal Investigator:||Marcelo Gama de Abreu||Dresden University|