The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease)
Inflammatory Bowel Disease (IBD) is an immune mediated chronic intestinal condition. It includes ulcerative colitis (UC) and Crohn's disease(CD). probiotics have been shown to be effective in varried clinical conditions ranging fron infantile diarrhea, necrotizing enterocolitis,helicobacter pylori infections, etc.
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||The Effect of Probiotics on the Rate of Recovery of Inflammatory Bowel Disease Exacerbation (Crohn's Disease) and Markers of Inflammation|
- endothelial stem cells [ Time Frame: one year ] [ Designated as safety issue: No ]to study the ability to create endothelial progenitor stem cells following probiotic management compared to placebo group
|Study Start Date:||February 2013|
|Estimated Study Completion Date:||February 2014|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|
To study the effect of probiotic on the ability to build endothelial progenitor stem cells and to study clinical recovery of patients with Crohn's Disease.
Clinical evaluation according to the Crohn's activity scale
Placebo Comparator: placebo
This will be the comparison group to the experimantal group that recives Probiotic.
This is a prospective study that will enroll 50 patients with Crohn's disease.Each patient will get the study medication for 6 weeks and will be evaluated twice- before enrollment and after 6 weeks of treatment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01765998
|Baruch Padeh Medical Center|
|Tiberias, Lower galilee, Israel, 15208|
|Principal Investigator:||Arnon Blum, MD||Baruch Padeh Medical Center|