The Effect of Laser-assisted Zona Thinning on the Implantation Rate in the Women of Advanced Age
The purpose of this study is to determine whether laser-assisted zona thinning improve the implantation rate of the women of advanced age in the first IVF/ICSI cycles
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||Center of Assisted Reproductive Technology|
- The implantation rate [ Time Frame: 30 days ] [ Designated as safety issue: Yes ]the implantation rate per embryo in first fresh embryos transfer cycles
- The miscarriage [ Time Frame: 24 weeks ] [ Designated as safety issue: Yes ]
|Study Start Date:||November 2013|
|Estimated Study Completion Date:||July 2015|
|Estimated Primary Completion Date:||January 2015 (Final data collection date for primary outcome measure)|
Experimental: Assisted hatching group (AH group)
The subjects are going to participate the treatment of assisted hatching in vitro fertilization by Zona Infrared Laser Optical System (ZILOS-TK IVOS Analyzer,Hamilton Thorne Biosciences,USA).
Device: ZILOS-TK IVOS Analyzer
The subjects are going to participate the treatment of assisted hatching in vitro fertilization by Zona Infrared Laser Optical System (ZILOS-TK,Hamilton Thorne Biosciences,USA)
No Intervention: Control group
The subjects are going to undergo the same procedure except for the treatment of assisted hatching.
- It's required to sign an informed consent form prior to the recruitment of all patients.
- Data collection and entry need double check and supervision.
The outcome measures:
the implantation rate per embryo transfer miscarriage live birth
Please refer to this study by its ClinicalTrials.gov identifier: NCT01765322
|Contact: Juanzi Shi, Doctoremail@example.com|
|Maternal and Children Health Care Hospital||Recruiting|
|Xi'an, Shaanxi, China, 710003|
|Contact: Wenhao Shi, Master +86-029-87219120 firstname.lastname@example.org|
|Study Director:||Wenhao Shi, Master||Maternal and Children Health Care Hospital|