inflAmmatory maRkers in Blood and Thrombus Aspirated From Patients With acutE myocaRdial Infarction With St-segment elevAtion (ARTERIA)
This study is currently recruiting participants.
Verified December 2012 by Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Sponsor:
Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Information provided by (Responsible Party):
Enrique Quintero, Fundación Canaria Rafael Clavijo para la Investigación Biomédica
ClinicalTrials.gov Identifier:
NCT01757886
First received: December 22, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The prognostic value of inflammatory markers in acute coronary syndrome has been extensively demonstrated, however it is still unknown whether there is an association between circulating and local (thrombus) inflammatory molecules, and the subset of molecules that provide better prognostic information in patients with ST-elevation acute coronary syndrome.
| Condition | Intervention |
|---|---|
|
Patients Admitted With the Diagnosis of ST-elevation Acute Coronary Syndrome |
Other: Biomarkers to analyze both intracoronary thrombi as blood |
| Study Type: | Observational [Patient Registry] |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Target Follow-Up Duration: | 12 Months |
Resource links provided by NLM:
Further study details as provided by Fundación Canaria Rafael Clavijo para la Investigación Biomédica:
Primary Outcome Measures:
- The primary objective of the study is to find out whether there is an association between certain inflammatory markers in blood and intracoronary thrombus and whether these markers are associated with the composite of all-cause mortality [ Time Frame: one year ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 100 |
| Study Start Date: | November 2012 |
| Estimated Study Completion Date: | November 2013 |
| Primary Completion Date: | November 2012 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
ST-elevation acute coronary syndrome
ARTERY is a prospective, multicenter, which will include patients admitted with the diagnosis of ST-elevation acute coronary syndrome and thrombus aspiration is performed during primary angioplasty
|
Other: Biomarkers to analyze both intracoronary thrombi as blood |
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Study Population
Pilot, prospective cohort, which included all patients admitted with a diagnosis of ST-elevation myocardial infarction and undergoing thrombus aspiration during a procedure effective emerging percutaneous coronary revascularization.
Criteria
Inclusion Criteria:
- They include patients of both sexes, without limits of age, with a diagnosis of STEMI within 12 hours after the beginning of symptoms. ST-elevation myocardial infarction was defined in the presence of symptoms consistent, persistent elevation (> 20 min) ST segment ≥ 1 mm in at least two contiguous leads or in the presence of left bundle branch block presumably new onset and cardiac troponin I elevation
Exclusion Criteria:
- Injury significant common core of left coronary artery (stenosis greater than or equal to 50% of the vessel lumen).
- Pre-Fibrinolysis percutaneous coronary intervention.
- Previous coronary bypass surgery.
- Thyrotoxicosis.
- Having an inflammatory systemic or local inflammatory process.
- Malignant neoplasm.
- Any disease that seriously compromise the prognosis and / or systemic inflammatory response generated.
- No thrombotic material obtained in the thrombus or insufficient for performing biochemical determinations.
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01757886
Contacts
| Contact: Alberto Dominguez-Rodriguez, MD, PhD | +34 922 679040 | adrvdg@hotmail.com |
Locations
| Spain | |
| Hospital Universitario de Canarias | Recruiting |
| La Laguna, Santa Cruz de Tenerife, Spain, E-38320 | |
| Contact: Alberto Dominguez-Rodriguez, MD, PhD +34 922 679040 adrvdg@hotmail.com | |
| Principal Investigator: Alberto Dominguez-Rodriguez, MD, PhD | |
| Hospital Universitario de Canarias | Recruiting |
| La Laguna, Santa Cruz de Tenerife, Spain, E-38320 | |
| Contact: Alberto Dominguez-Rodriguez, MD, PhD +34 922679040 adrvdg@hotmail.com | |
| Hospital Universitario de Canarias | Recruiting |
| La Laguna, Tenerife, Spain, 38320 | |
| Contact: Alberto Dominguez-Rodriguez, MD, PhD +34 922 679040 adrvdg@hotmail.com | |
Sponsors and Collaborators
Fundación Canaria Rafael Clavijo para la Investigación Biomédica
Investigators
| Study Chair: | Alberto Dominguez-Rodriguez, MD, PhD | Hospital Universitario de Canarias |
More Information
No publications provided
| Responsible Party: | Enrique Quintero, Alberto Dominguez Rodriguez, Fundación Canaria Rafael Clavijo para la Investigación Biomédica |
| ClinicalTrials.gov Identifier: | NCT01757886 History of Changes |
| Other Study ID Numbers: | ARTERIA-2012, ARTERIA-2012 |
| Study First Received: | December 22, 2012 |
| Last Updated: | December 22, 2012 |
| Health Authority: | Spain: Ethics Committee |
Keywords provided by Fundación Canaria Rafael Clavijo para la Investigación Biomédica:
|
Myocardial infarction, Inflammation, Thrombus, Coronary angioplasty. |
Additional relevant MeSH terms:
|
Myocardial Infarction Acute Coronary Syndrome Myocardial Ischemia Heart Diseases Cardiovascular Diseases |
Vascular Diseases Angina Pectoris Chest Pain Pain Signs and Symptoms |
ClinicalTrials.gov processed this record on May 16, 2013