Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

This study has been completed.
Sponsor:
Collaborator:
Barnes-Jewish Hospital
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT01752868
First received: December 14, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
  Purpose

The purpose of this study is to determine if a combination of 10 nutritional supplements provide health benefits that are consistent with protection against age-related disease. All supplements have been shown in previous studies to have health benefits when administered alone. The hypothesis is that 6 months of taking 10 nutritional supplements each day will provide beneficial changes in healthy related measures.


Condition Intervention
Healthy Volunteers
Dietary Supplement: Supplement

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

Resource links provided by NLM:


Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Carotid-femoral pulse wave velocity [ Time Frame: Baseline and 6 months ] [ Designated as safety issue: No ]

Enrollment: 56
Study Start Date: May 2011
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: supplement Dietary Supplement: Supplement
Participants in this group will take the following nutritional supplements on a daily basis: curcumin, fish oil, resveratrol, sesamin, Acetyl-L-carnitine, lipoic acid, green and black teas, quercetin, pomegranate, cinnamon bark.
No Intervention: control

  Eligibility

Ages Eligible for Study:   40 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 40-60 yr
  • body mass index of 21 - 30 kg/m2
  • sedentary to moderately active
  • eating a typical US diet

Exclusion Criteria:

  • history of any chronic disease other than mild osteoarthritis
  • use of medications other than occasional use of non-steroidal anti-inflammatory drugs, antihistamines, antacids or laxatives
  • use of nutritional supplements
  • smoking
  • alcohol intake greater than two drinks per day for women and three drinks per day for men
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01752868

Locations
United States, Missouri
Washington University Medical Center
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Barnes-Jewish Hospital
Investigators
Principal Investigator: Luigi Fontana, MD, PhD Washington University Early Recognition Center
  More Information

No publications provided

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01752868     History of Changes
Other Study ID Numbers: BJH 6936-33
Study First Received: December 14, 2012
Last Updated: December 14, 2012
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on July 31, 2014