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Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

This study has been completed.
Sponsor:
Collaborator:
Barnes-Jewish Hospital
Information provided by (Responsible Party):
Washington University School of Medicine
ClinicalTrials.gov Identifier:
NCT01752868
First received: December 14, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
  Purpose

The purpose of this study is to determine if a combination of 10 nutritional supplements provide health benefits that are consistent with protection against age-related disease. All supplements have been shown in previous studies to have health benefits when administered alone. The hypothesis is that 6 months of taking 10 nutritional supplements each day will provide beneficial changes in healthy related measures.


Condition Intervention
Healthy Volunteers
 Dietary Supplement: Supplement

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Can Fish Oil and Phytochemical Supplements Mimic Anti-Aging Effects of Calorie Restriction?

Resource links provided by NLM:

Drug Information available for: Fish oil
U.S. FDA Resources

Further study details as provided by Washington University School of Medicine:

Primary Outcome Measures:
  • Carotid-femoral pulse wave velocity [ Time Frame: Baseline and 6 months ] [ Designated as safety issue: No ]

Enrollment: 56
Study Start Date: May 2011
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: supplement Dietary Supplement: Supplement
Participants in this group will take the following nutritional supplements on a daily basis: curcumin, fish oil, resveratrol, sesamin, Acetyl-L-carnitine, lipoic acid, green and black teas, quercetin, pomegranate, cinnamon bark.
No Intervention: control

  Eligibility

Ages Eligible for Study:   40 Years to 60 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • age 40-60 yr
  • body mass index of 21 - 30 kg/m2
  • sedentary to moderately active
  • eating a typical US diet

Exclusion Criteria:

  • history of any chronic disease other than mild osteoarthritis
  • use of medications other than occasional use of non-steroidal anti-inflammatory drugs, antihistamines, antacids or laxatives
  • use of nutritional supplements
  • smoking
  • alcohol intake greater than two drinks per day for women and three drinks per day for men
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01752868

Locations
United States, Missouri
Washington University Medical Center
St. Louis, Missouri, United States, 63110
Sponsors and Collaborators
Washington University School of Medicine
Barnes-Jewish Hospital
Investigators
Principal Investigator: Luigi Fontana, MD, PhD Washington University School of Medicine
  More Information

No publications provided

Responsible Party: Washington University School of Medicine
ClinicalTrials.gov Identifier: NCT01752868     History of Changes
Other Study ID Numbers: BJH 6936-33
Study First Received: December 14, 2012
Last Updated: December 14, 2012
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on May 21, 2013