Study on Correlation Between Vascular ET-1 and Adiponectin in Pediatric Obesity
This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Monica Montagnani, Montagnani, Monica, M.D., Ph.D.
First received: December 12, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
The aim of this study is to explore whether and how high circulating levels of endothelin-1 (ET-1) in obese and overweight children may contribute to impair adiponectin (Ad) production, release and vascular activity
||Observational Model: Cohort
Time Perspective: Retrospective
||Observational Retrospective Study on Correlation Between ET-1 and Ad in Obese Children
Biospecimen Retention: Samples Without DNA
Primary Outcome Measures:
- Correlation between serum levels of ET-1 and Ad in lean, overweight and obese children [ Time Frame: 12 months ] [ Designated as safety issue: No ]
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Estimated Primary Completion Date:
||March 2013 (Final data collection date for primary outcome measure)
Overweight Children (OW)
Obese children (Ob)
|Ages Eligible for Study:
||5 Years to 13 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
CHILDREN ATTENDING THE OUTPATIENT UNIT OF THE UNIVERSITY PEDIATRIC CLINIC
- Children will be enrolled into lean, overweight or obese groups based on Body mass index (BMI) calculated according to standard methods. International standards for sex-and age-specific BMI centiles for subjects aged 2-18 years will be used. The 95th centile of BMI reference is the cut off point for childhood obesity. Overweight and obese children are defined as those with a BMI higher than the centile curves.
- presence of renal, liver and/or cardiovascular diseases;
- metabolic and/or endocrine disorders;
- genetic syndromes;
- histories of chronic allergies, acute infectious or inflammatory diseases during the last 3 months preceding the study
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01750333
|University of Bari Medical School - Dept Biomedical Sciences and Human Oncology
|Bari, Italy, 70124 |
||Monica Montagnani, MD, PhD
||University of Bari Medical School
No publications provided
||Monica Montagnani, Medical School Faculty Member - Professor of Pharmacology, Montagnani, Monica, M.D., Ph.D.
History of Changes
|Other Study ID Numbers:
|Study First Received:
||December 12, 2012
||December 12, 2012
||Italy: Ministry of Health
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on October 21, 2014
Glucose Metabolism Disorders
Signs and Symptoms