Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot
This study is ongoing, but not recruiting participants.
Sponsor:
Ohio State University
Collaborator:
University of Costa Rica, University of Hohenheim
Information provided by (Responsible Party):
Steven Schwartz, Ohio State University
ClinicalTrials.gov Identifier:
NCT01748916
First received: December 3, 2012
Last updated: December 12, 2012
Last verified: December 2012
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Purpose
The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes. This objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from subjects who consumed a meal containing fresh papaya, tomato, and carrot.
| Condition | Intervention |
|---|---|
|
Focus of Study: Carotenoid Absorption |
Other: Papaya Other: Carrot Other: Tomato |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Pharmacokinetics Study Intervention Model: Crossover Assignment Masking: Open Label Primary Purpose: Basic Science |
| Official Title: | Evaluation of the Effect of the Consumption of Papaya, Tomato, and Carrot on the Bioavailability of Carotenoids |
Resource links provided by NLM:
Further study details as provided by Ohio State University:
Primary Outcome Measures:
- Pharmacokinetics of carotenoid absorption from papaya, carrot and tomato [ Time Frame: 8 post-prandial blood samples over 9.5 hours ] [ Designated as safety issue: No ]The primary goal of this research is to investigate whether papaya can deliver increased quantities of carotenoids when compared to carrot and tomato. An area under the curve for concentration of carotenoids (from triglyceride rich lipoprotein (TRL) fraction of plasma) over time will be determined to quantify absorption, after subjects consume a meal containing papaya, carrot or tomato.
| Enrollment: | 16 |
| Study Start Date: | June 2011 |
| Estimated Study Completion Date: | October 2014 |
| Primary Completion Date: | November 2011 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: Papaya-Carrot-Tomato
Test meals were consumed in the following order: 1. Papaya 2. Carrot 3. Tomato.
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
|
Experimental: Papaya-Tomato-Carrot
Test meals were consumed in the following order: 1. Papaya 2. Tomato 3. Carrot
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
|
Experimental: Tomato-Papaya-Carrot
Test meals were consumed in the following order: 1. Tomato 2. Papaya 3. Carrot
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
|
Experimental: Tomato-Carrot-Papaya
Test meals were consumed in the following order: 1. Tomato 2. Carrot 3. Papaya
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
|
Experimental: Carrot-Papaya-Tomato
Test meals were consumed in the following order: 1. Carrot 2. Papaya 3. Tomato
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
|
Experimental: Carrot-Tomato-Papaya
Test meals were consumed in the following order: 1. Carrot 2. Tomato 3. Papaya
|
Other: Papaya
Post-prandial study feeding 400-506 g papaya (1.6 mg beta-carotene, 2.1 mg beta-cryptoxanthin, 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Carrot
Post-prandial study feeding 25-35 g carrot (= 1.6 mg beta-carotene), 150 g yogurt (10% fat), and 45 g of fat free bread.
Other: Tomato
Post-prandial study feeding 256-396 g tomato (= 13 mg lycopene), 150 g yogurt (10% fat), and 45 g of fat free bread.
|
Detailed Description:
The main purpose of this study is comparing bioavailability of papaya carotenoids versus carrot and tomato carotenoids. Previously, vitamin A deposition in rat livers was studied, showing that carotenoid bioavailability from papaya is higher than from spinach, parsley and carrots. Detailed knowledge about human carotenoid absorption and conversion from papaya fruit compared to other food sources is still lacking.
Eligibility| Ages Eligible for Study: | 18 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- healthy individuals
Exclusion Criteria:
- lactating, pregnant, or planned to be pregnant
- smokers/those who use tobacco products
- metabolic or malabsorption disorders
- had a history of cancer
- history of liver insufficiency or other gastro-intestinal diseases
- allergy to papaya, carrots or tomatoes
- obesity
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01748916
Locations
| United States, Ohio | |
| The Ohio State University | |
| Columbus, Ohio, United States, 43210 | |
| Costa Rica | |
| University of Costa Rica | |
| San José, Costa Rica | |
Sponsors and Collaborators
Ohio State University
University of Costa Rica, University of Hohenheim
Investigators
| Principal Investigator: | Steven J Schwartz, Ph.D. | Ohio State University |
More Information
No publications provided
| Responsible Party: | Steven Schwartz, Professor, Ohio State University |
| ClinicalTrials.gov Identifier: | NCT01748916 History of Changes |
| Other Study ID Numbers: | 2011H0336 |
| Study First Received: | December 3, 2012 |
| Last Updated: | December 12, 2012 |
| Health Authority: | United States: Institutional Review Board Costa Rica: Ethics Committee |
Keywords provided by Ohio State University:
|
Papaya Carrot Tomato Carotenoids |
Lycopene Beta-carotene Beta-cryptoxanthin |
Additional relevant MeSH terms:
|
Carotenoids Cryptoxanthin Beta Carotene Antioxidants Molecular Mechanisms of Pharmacological Action Pharmacologic Actions Protective Agents |
Physiological Effects of Drugs Vitamins Micronutrients Growth Substances Anticarcinogenic Agents Antineoplastic Agents Therapeutic Uses |
ClinicalTrials.gov processed this record on June 17, 2013