Microcirculation of the Thenar Eminence
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Purpose
Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome. Investigators aimed at firstly describing microcirculation with near infra red spectroscopy (NIRS) and secondly correlating NIRS parameters with intensive care length of stay and organ dysfunction.
| Condition | Intervention |
|---|---|
|
Elective Cardiac Surgery |
Other: microcirculatory reactivity |
| Study Type: | Observational |
| Study Design: | Observational Model: Cohort Time Perspective: Prospective |
| Official Title: | Interest of the Measure of the StO2 to Estimate the Microcirculatory Disturbances Following Cardiac Surgery With Cardiopulmonary Bypass |
- microcirculatory reactivity [ Time Frame: 10 minutes before anesthésia induction ] [ Designated as safety issue: No ]Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence
- microcirculatory reactivity [ Time Frame: during CPB (30 minutes after the start), and 2, 6, 12, 24 and 48 hours after the end of the CPB ] [ Designated as safety issue: No ]Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence
| Enrollment: | 40 |
| Study Start Date: | April 2010 |
| Study Completion Date: | August 2011 |
| Primary Completion Date: | August 2011 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
microcirculatory reactivity
Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge.
|
Other: microcirculatory reactivity
Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge.
|
Detailed Description:
40 patients at high risk of post operative systemic inflammatory response syndrome after an elective cardiac surgery with CPB were included in this prospective observational study. Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge. Organ dysfunction was assessed with the SOFA score.
Eligibility| Ages Eligible for Study: | 18 Years to 90 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
patients at high risk of post operative systemic inflammatory response syndrome after an elective cardiac surgery with CPB
Inclusion Criteria:
- Age > 18 years
- scheduled for an elective cardiac surgery at high risk of post operative systemic inflammatory response syndrome
Exclusion Criteria:
- BMI>35
Contacts and Locations More Information
No publications provided
| Responsible Party: | Centre Hospitalier Universitaire de Saint Etienne |
| ClinicalTrials.gov Identifier: | NCT01748266 History of Changes |
| Other Study ID Numbers: | 1008018, 2010-A00172-37 |
| Study First Received: | December 7, 2012 |
| Last Updated: | December 11, 2012 |
| Health Authority: | France: L’Agence nationale de sécurité du médicament et des produits de santé |
Keywords provided by Centre Hospitalier Universitaire de Saint Etienne:
|
StO2 microcirculation NIRS |
ClinicalTrials.gov processed this record on May 21, 2013