Short-term Cognitive Training in Late-life Depression

This study is currently recruiting participants. (see Contacts and Locations)
Verified December 2012 by Rotman Research Institute at Baycrest
Sponsor:
Collaborator:
Baycrest
Information provided by (Responsible Party):
Dr. Linda Mah, Rotman Research Institute at Baycrest
ClinicalTrials.gov Identifier:
NCT01748032
First received: December 10, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
  Purpose

The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD).

The hypotheses are:

  1. post-training cognitive performance will be superior to pre-training cognitive performance
  2. post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and
  3. AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.

Condition Intervention
Depression
Behavioral: Cognitive training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Treatment
Official Title: The Effects of Short-term Cognitive Training on Cognition and Mood Symptoms in Late-life Depression: A Pilot Study

Resource links provided by NLM:


Further study details as provided by Rotman Research Institute at Baycrest:

Primary Outcome Measures:
  • Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ] [ Designated as safety issue: No ]

    Computerized Executive Tasks:

    • Number-Letter Task
    • Letter-Memory Task
    • Stroop Task

    Non-Computerized Measures:

    • Cattell Culture Fair Intelligence Test
    • Mattis Dementia Rating Scale-2 (DRS-2)


Secondary Outcome Measures:
  • Changes in mood including depression, anxiety and apathy [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ] [ Designated as safety issue: No ]
    • Montgomery Asberg Depression Rating Scale (MADRS)
    • Apathy Evaluation Scale (AES)
    • Hamilton Anxiety Rating Scale (Ham-A)
    • Beck Depression Inventory (BDI)


Estimated Enrollment: 30
Study Start Date: August 2012
Estimated Study Completion Date: September 2013
Estimated Primary Completion Date: June 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Alternative Uses Training
In this task, subjects are asked to produce atypical and alternative uses for common daily objects.
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention
Word Association Training
In this task, subjects are asked to generate the first word that comes to their mind, and thus, encourages more general and spontaneous divergent thinking.
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention

  Eligibility

Ages Eligible for Study:   55 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Male or female
  • Age >=55
  • Proficiency in English
  • Current depressive episode and meet criteria for DSM-IV major depressive disorder
  • Hamilton Depression Rating Scale score >=15
  • Able to give informed consent
  • Stable medication dosages during the training period

Exclusion Criteria:

  • Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders
  • Mini-Mental State Examination score of <26
  • Diagnosis of dementia
  • Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)
  • Unstable medical illnesses requiring active treatment
  • Vision or hearing impairment affecting ability to participate in training
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01748032

Contacts
Contact: Ming-Ching Wen, PhD 416-785-2500 ext 2757 mwen@research.baycrest.org
Contact: Linda Mah, MD, M.H.Sc. 416-785-2500 ext 3365 lmah@research.baycrest.org

Locations
Canada, Ontario
Rotman Research Institute at Baycrest Recruiting
Toronto, Ontario, Canada, M6A 2E1
Sponsors and Collaborators
Rotman Research Institute at Baycrest
Baycrest
Investigators
Principal Investigator: Linda Mah, MD, M.H.Sc. Rotman Research Institute at Baycrest
  More Information

No publications provided

Responsible Party: Dr. Linda Mah, Clinician Scientist, Rotman Research Institute at Baycrest
ClinicalTrials.gov Identifier: NCT01748032     History of Changes
Other Study ID Numbers: 12-28
Study First Received: December 10, 2012
Last Updated: December 10, 2012
Health Authority: Canada: Ethics Review Committee

Keywords provided by Rotman Research Institute at Baycrest:
depression
intervention studies

Additional relevant MeSH terms:
Depression
Depressive Disorder
Behavioral Symptoms
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on July 26, 2014