Short-term Cognitive Training in Late-life Depression
This study is currently recruiting participants.
Verified December 2012 by Rotman Research Institute at Baycrest
Sponsor:
Rotman Research Institute at Baycrest
Collaborator:
Baycrest
Information provided by (Responsible Party):
Dr. Linda Mah, Rotman Research Institute at Baycrest
ClinicalTrials.gov Identifier:
NCT01748032
First received: December 10, 2012
Last updated: NA
Last verified: December 2012
History: No changes posted
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Purpose
The purpose of this study is to examine the effects of the alternative uses training (AUT) and word association training (WAT) on cognitive functions and mood symptoms in late-life depression (LLD).
The hypotheses are:
- post-training cognitive performance will be superior to pre-training cognitive performance
- post-training depressive symptomatology will be less severe as compared with pre-training clinical severity and
- AUT group will show better post-training cognitive performance and improved mood symptoms when compared with the WAT group.
| Condition | Intervention |
|---|---|
|
Depression |
Behavioral: Cognitive training |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator) Primary Purpose: Treatment |
| Official Title: | The Effects of Short-term Cognitive Training on Cognition and Mood Symptoms in Late-life Depression: A Pilot Study |
Resource links provided by NLM:
Further study details as provided by Rotman Research Institute at Baycrest:
Primary Outcome Measures:
- Changes in cognitive functions including fluid intelligence, executive function, language, memory and motor speed [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ] [ Designated as safety issue: No ]
Computerized Executive Tasks:
- Number-Letter Task
- Letter-Memory Task
- Stroop Task
Non-Computerized Measures:
- Cattell Culture Fair Intelligence Test
- Mattis Dementia Rating Scale-2 (DRS-2)
Secondary Outcome Measures:
- Changes in mood including depression, anxiety and apathy [ Time Frame: Within 3 days before the first cognitive training day and within 3 days after the last cognitive training day ] [ Designated as safety issue: No ]
- Montgomery Asberg Depression Rating Scale (MADRS)
- Apathy Evaluation Scale (AES)
- Hamilton Anxiety Rating Scale (Ham-A)
- Beck Depression Inventory (BDI)
| Estimated Enrollment: | 30 |
| Study Start Date: | August 2012 |
| Estimated Study Completion Date: | September 2013 |
| Estimated Primary Completion Date: | June 2013 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Alternative Uses Training
In this task, subjects are asked to produce atypical and alternative uses for common daily objects.
|
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention
|
|
Word Association Training
In this task, subjects are asked to generate the first word that comes to their mind, and thus, encourages more general and spontaneous divergent thinking.
|
Behavioral: Cognitive training
20 minutes/day for 5 sequential working days
Other Name: cognitive intervention
|
Eligibility| Ages Eligible for Study: | 55 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Male or female
- Age >=55
- Proficiency in English
- Current depressive episode and meet criteria for DSM-IV major depressive disorder
- Hamilton Depression Rating Scale score >=15
- Able to give informed consent
- Stable medication dosages during the training period
Exclusion Criteria:
- Other DSM-IV Axis I psychiatric disorders, except for anxiety disorders due to high comorbidity with mood disorders
- Mini-Mental State Examination score of <26
- Diagnosis of dementia
- Neurological and medical conditions known to affect cognition (e.g., stroke, head injury, previous chemotherapy for cancer)
- Unstable medical illnesses requiring active treatment
- Vision or hearing impairment affecting ability to participate in training
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01748032
Contacts
| Contact: Ming-Ching Wen, PhD | 416-785-2500 ext 2757 | mwen@research.baycrest.org |
| Contact: Linda Mah, MD, M.H.Sc. | 416-785-2500 ext 3365 | lmah@research.baycrest.org |
Locations
| Canada, Ontario | |
| Rotman Research Institute at Baycrest | Recruiting |
| Toronto, Ontario, Canada, M6A 2E1 | |
Sponsors and Collaborators
Rotman Research Institute at Baycrest
Baycrest
Investigators
| Principal Investigator: | Linda Mah, MD, M.H.Sc. | Rotman Research Institute at Baycrest |
More Information
No publications provided
| Responsible Party: | Dr. Linda Mah, Clinician Scientist, Rotman Research Institute at Baycrest |
| ClinicalTrials.gov Identifier: | NCT01748032 History of Changes |
| Other Study ID Numbers: | 12-28 |
| Study First Received: | December 10, 2012 |
| Last Updated: | December 10, 2012 |
| Health Authority: | Canada: Ethics Review Committee |
Keywords provided by Rotman Research Institute at Baycrest:
|
depression intervention studies |
Additional relevant MeSH terms:
|
Depression Depressive Disorder Behavioral Symptoms Mood Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 21, 2013