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Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC)

This study is ongoing, but not recruiting participants.
Sponsor:
Information provided by (Responsible Party):
Athanassios Dellas, MD, University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier:
NCT01732432
First received: November 18, 2012
Last updated: NA
Last verified: November 2012
History: No changes posted
  Purpose

The purpose of this study is to determine whether a relationship exists between a previously established diagnosis of endometriosis and the consecutive risk of developing a clear cell or endometrioid ovarian carcinoma. All histopathological records since 1980 with these diagnoses (endometriosis, clear cell and endometrioid ovarian carcinoma) will be reviewed. Cancer registry data will be assessed to investigate differences in survival of women with endometriosis-associated ovarian carcinomas and those ovarian carcinoma patients without previous diagnosis of endometriosis.


Condition
Endometrioid Carcinoma
Clear Cell Carcinoma
Endometriosis

Study Type: Observational
Study Design: Time Perspective: Retrospective
Official Title: Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC) - Epidemiological and Molecular Pathological Aspects

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by University Hospital, Basel, Switzerland:

Primary Outcome Measures:
  • incidence and clinical outcome of endometriosis-associated ovarian carcinomas [ Time Frame: 30 years ] [ Designated as safety issue: No ]

Estimated Enrollment: 200
Study Start Date: October 2012
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: August 2013 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   30 Years to 85 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

primary care hospital, university hospital

Criteria

Inclusion Criteria:

  • endometrioid ovarian carcinoma
  • clear cell ovarian carcinoma
  • endometriosis, atypical endometriosis
  • borderline tumors with endometriosis

Exclusion Criteria:

  • undifferentiated carcinomas
  • germ cell tumors
  • sex cord-stromal tumors
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01732432

Sponsors and Collaborators
University Hospital, Basel, Switzerland
Investigators
Principal Investigator: Athanassios Dellas, MD University Hospital Basel, University of Basel
Principal Investigator: Ellen C Obermann, MD Institute of Pathology, University Hospital Basel, University of Basel
  More Information

No publications provided

Responsible Party: Athanassios Dellas, MD, Associate-Professor of Obstetrics and Gynecology, University Hospital, Basel, Switzerland
ClinicalTrials.gov Identifier: NCT01732432     History of Changes
Other Study ID Numbers: 210/12
Study First Received: November 18, 2012
Last Updated: November 18, 2012
Health Authority: Switzerland: Ethikkommission
Switzerland: Federal Office of Public Health

Additional relevant MeSH terms:
Carcinoma
Endometriosis
Ovarian Neoplasms
Adenocarcinoma, Clear Cell
Adenomyoepithelioma
Carcinoma, Endometrioid
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Neoplasms
Genital Diseases, Female
Endocrine Gland Neoplasms
 Neoplasms by Site
Ovarian Diseases
Adnexal Diseases
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Adenocarcinoma
Neoplasms, Complex and Mixed
Endometrial Neoplasms
Uterine Neoplasms

ClinicalTrials.gov processed this record on May 23, 2013