Arterial Wall Calcium Load in Pseudoxanthoma Elasticum (Ca-Art-PXE2)
Quantification and preferential sites of arterial wall calcification within the coronary and lower legs arteries will be comared between Pseudo-Xanthoma elasticum(PXE) atients and type 2 diabetics and Chronic Kidney disease.
Type 2 Diabetes
Chronic Kidney Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Arterial Wall Calcium Load and Preferential Sites in Pseudoxanthoma Elasticum Versus Type 2 Diabetes and Chronic Kidney Disease.|
- calcification score [ Time Frame: after inclusion ] [ Designated as safety issue: No ]the level of arterial wall calcification determined by a Ct-scan and computed by the Agatston score
- site of calcification [ Time Frame: after inclusion ] [ Designated as safety issue: No ]the anatomical site of arterial wall calcification determined by a Ct-scan and computed by the Agatston score
Biospecimen Retention: Samples With DNA
|Study Start Date:||January 2012|
|Estimated Study Completion Date:||July 2013|
|Estimated Primary Completion Date:||July 2013 (Final data collection date for primary outcome measure)|
Patients with genetically and clincally proven PXE
chronic kidney disease
Type 2 diabetic patients with mediacalcosis and matched to PXE patients for gender and age (+/- 5 yrs).
patients with chronic kidney disease and matched to PXE patients for gender and age (+/- 5 yrs).
In a previous work we have observed that patients suffering from PXE, a soft-tissue calcifying inherited autosomal disease, exhibited specific structural and functionnal features within the peripheral arteries. We now want to quantify and determine the preferential sites of the arterial wall calcification (Agatston score) between these patients compared to diabetics and patients with chronic renal insufficiency with mediacalcosis.
All variables will be collected from a cohort of PXE monitored in our PXE Health and Care centre at the university hospital of Angers. Quantification of the arterial wall calcium load will be performed using helicoidal CT-scan. These variables will be compared to the same measurements performed in type 2 diabetic and chronic kidney disease patients paired by age and gender.
|Contact: Yannick LE CORRE, MD||33(2)email@example.com|
|Contact: Ludovic MARTIN, MD, PhD||33(2)firstname.lastname@example.org|
|Angers, Pays de la Loire, France, 49933|
|Contact: Ludovic MARTIN, MD, PhD 33(2)126.96.36.199 email@example.com|
|Contact: Georges LEFTHERIOTIS, MD, PhD 33(2)188.8.131.52 firstname.lastname@example.org|
|Principal Investigator: Yannick LE CORRE, MD|
|Sub-Investigator: Ludovic MARTIN, MD, PhD|
|Sub-Investigator: Georges LEFTHERIOTIS, MD, PhD|
|Sub-Investigator: Pierre ABRAHAM, MD, PhD|
|Sub-Investigator: Serge WILLOTEAUX, MD, PhD|
|Sub-Investigator: Jean-Francois SUBRA, MD, PhD|
|Sub-Investigator: Pierre-Henri DUCLUZEAU, MD|
|Principal Investigator:||Yannick LE CORRE, MD||Department of Dermatology, University Hospital of Angers, France|