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Satiety Effects on the Neural Valuation of Food

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2012 by Duke-NUS Graduate Medical School.
Recruitment status was  Recruiting
Sponsor:
Collaborator:
Singapore Institute for Clinical Sciences
Information provided by (Responsible Party):
MChee, Duke-NUS Graduate Medical School
ClinicalTrials.gov Identifier:
NCT01721187
First received: October 23, 2012
Last updated: November 1, 2012
Last verified: November 2012
  Purpose

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.


Condition
Fasting
Fed

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety

Further study details as provided by Duke-NUS Graduate Medical School:

Primary Outcome Measures:
  • fMRI - Willingness to Pay task (BDM auction) [ Time Frame: Fed and fasted visits (Wks 1 & 2) ] [ Designated as safety issue: No ]
    A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.

  • fMRI - Monetary and Food Incentive Delay task [ Time Frame: Fed and fasted visits (Wks 1 & 2) ] [ Designated as safety issue: No ]
    A measurement of neural response to anticipating and receiving money and food rewards.


Biospecimen Retention:   None Retained

(NA)


Estimated Enrollment: 60
Study Start Date: October 2012
Estimated Study Completion Date: July 2014
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Low disinhibition
fMRI during fed and fasted states
High disinhibition
fMRI during fed and fasted states

  Eligibility

Ages Eligible for Study:   21 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community sample

Criteria

Inclusion Criteria:

  • Chinese ethnicity
  • 21 to 45 years old
  • English as first language
  • Right-handed
  • Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
  • Weigh less than 100kg with an abdominal circumference of less than 120cm
  • Non-smoker, or only smoke occasionally (less than 5 sticks a week)
  • Consume less than 2 units (200 mg) of caffeine a day
  • Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
  • Habitually sleep before 1am and wake before 9am

Exclusion Criteria:

  • On a restrictive diet (e.g., vegetarian/vegan diet)
  • History of food allergies
  • History of psychiatric or neurological disorders
  • History of chronic medical illness
  • Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
  • Shift worker
  • Claustrophobic
  • High astigmatism (high = >2.00 diopters)
  • Colour-blind
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01721187

Contacts
Contact: Mingyi Zhou 65164457 vofiovofio@gmail.com

Locations
Singapore
Centre for Cognitive Neuroscience scanner suite Recruiting
Singapore, Singapore, 169611
Contact    65164457    vofiovofio@gmail.com   
Principal Investigator: Michael WL Chee, MBBS         
Sponsors and Collaborators
Duke-NUS Graduate Medical School
Singapore Institute for Clinical Sciences
Investigators
Principal Investigator: Michael WL Chee, MBBS Duke-NUS Graduate Medical School
  More Information

Publications:
Responsible Party: MChee, Professor, Duke-NUS Graduate Medical School
ClinicalTrials.gov Identifier: NCT01721187     History of Changes
Other Study ID Numbers: VOFIO3G
Study First Received: October 23, 2012
Last Updated: November 1, 2012
Health Authority: Singapore: Institutional Review Board

Keywords provided by Duke-NUS Graduate Medical School:
fMRI
Satiety
Willingness to Pay
Incentive Delay
Dietary Disinhibition

ClinicalTrials.gov processed this record on November 19, 2014