The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease
Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.
Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
- Serum levels of angiogenin in Behçet's patients with or without ocular involvement [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance.
- Serum levels of bFGF in Behçet's patients with or without ocular involvement [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
- Serum levels of VEGF in Behçet's patients with or without ocular involvement [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
|Study Start Date:||November 2011|
|Study Completion Date:||February 2012|
|Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|
Serum levels of angiogenin, bFGF, VEGF levels in Behçet's patients with ocular involvement group, without ocular involvement group and control group
Other: serum levels of angiogenin, bFGF, VEGF
|Ankara University, Faculty of Medicine, Department of Ophthalmology|
|Ankara, Turkey, 06620|
|Study Director:||ali yalçındağ||* Dışkapı Yıldırım Beyazıt Training and Research Hospital, Department of Clinical Biochemistry|