Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study (STOP-Uveitis)

This study is not yet open for participant recruitment. (see Contacts and Locations)
Verified October 2012 by Johns Hopkins University
Sponsor:
Information provided by (Responsible Party):
Quan Dong Nguyen, Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT01717170
First received: October 26, 2012
Last updated: NA
Last verified: October 2012
History: No changes posted
  Purpose

In the STOP-UVEITIS study, we propose to evaluate the safety, tolerability, and bioactivity of two doses of Tocilizumab (4mg/kg and 8mg/kg), administered monthly, in patients with non-infectious intermediate, posterior, or panuveitis.


Condition Intervention Phase
Non-infectious Intermediate, Posterior, or Pan-uveitis.
Drug: Tocilizumab
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Study of the Safety, Tolerability, and Bioactivity of Tocilizumab On Patients With Non-infectious UVEITIS: The STOP-UVEITIS Study

Resource links provided by NLM:


Further study details as provided by Johns Hopkins University:

Primary Outcome Measures:
  • Frequency and severity of adverse events from baseline (BL) to month 6. [ Time Frame: Baseline (BL) to month 6. ] [ Designated as safety issue: Yes ]
    Safety and tolerability of repeated Tocilizumab infusions in patients with non-infectious uveitis, as assessed by frequency and severity of adverse events from baseline (BL) to month 6.


Secondary Outcome Measures:
  • Frequency and severity of adverse events at month 12. [ Time Frame: Baseline to Month 12 ] [ Designated as safety issue: Yes ]
    Safety and tolerability of repeated Tocilizumab infusions in patients with non-infectious uveitis, as assessed by frequency and severity of adverse events at month 12.


Other Outcome Measures:
  • Percentage of patients with a decrease of ≥ 2 steps in vitreous haze or resolution of haze (for patients with 1+ haze at baseline) based on the National Eye Institute (NEI) scale at 1, 3, 6, and 12 months after therapy or at time of rescue. [ Time Frame: Months 1, 3, 6, and 12 after therapy or at the time of rescue therapy administration. ] [ Designated as safety issue: No ]
    Percentage of patients with a decrease of ≥ 2 steps in vitreous haze or resolution of haze (for patients with 1+ haze at baseline) based on the National Eye Institute (NEI) scale at 1, 3, 6, and 12 months after therapy or at time of rescue. All patients who receive rescue therapy will be followed until the conclusion of month 12.


Estimated Enrollment: 36
Arms Assigned Interventions
Experimental: Tocilizumab (4 mg/kg)
Tocilizumab (4 mg/kg) as an intravenous infusion over 1 hour at day 0, 30, 60, 90, 120, and 150.
Drug: Tocilizumab
Tocilizumab (4 mg/kg or 8 mg/kg)
Other Name: ACTEMRA
Experimental: Tocilizumab (8 mg/kg)
Tocilizumab (8 mg/kg) as an intravenous infusion over 1 hour at day 0, 30, 60, 90, 120, and 150.
Drug: Tocilizumab
Tocilizumab (4 mg/kg or 8 mg/kg)
Other Name: ACTEMRA

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Age ≥ 18;
  • Able to give informed consent and attend all study visits;
  • Have diagnosis of uveitis determined by the Investigator to be non-infectious;
  • Have active uveitis, defined as having at least 1+ Vitreous Haze (SUN scale) in study eye. As mentioned above, at least 12 of the randomized subjects must also have vitreous haze of ≥ 2+ vitreous haze. and:
  • are receiving no other treatment; or,
  • are receiving prednisone ≥10 mg/day (or equivalent dose of another corticosteroid) and/or at least 1 other systemic immunosuppressant;
  • Have posterior, intermediate, or panuveitis; for panuveitis, if an anterior component is present, it must be less than the posterior component;
  • Sufficient inflammation to require systemic treatment or long-term regional treatment. Patients whom the investigators feel may only need short-term topical therapy should not be enrolled.
  • Best-corrected (ETDRS) visual acuity of 20/20 to 20/400 (approximately 80 to 20 letters) in the study eye;
  • Best- corrected ETDRS visual acuity of 20/400 or better in the fellow eye (approximately 20 letters).
  • Must have a chest radiograph within 3 months prior to enrollment with no evidence of malignancy, infection or fibrosis.
  • Females of childbearing potential must have a negative serum pregnancy test at screening. In addition, sexually active females of childbearing potential must agree to use TWO of the following adequate forms of contraception while on study medication: oral, injectable, or implantable hormonal contraceptives; tubal ligation; intrauterine device; barrier contraceptive with spermicide; or vasectomized partner.
  • Males must agree to use barrier contraception (latex condoms) when engaging in sexual activity while on study medication and for 28 days after taking the last dose of study medication.
  • Subjects with a documented history of non-infectious intermediate-, anterior and intermediate, posterior, or pan-uveitis including but not restricted to: intermediate uveitis, sarcoidosis, Vogt-Koyanagi-Harada (VKH) syndrome, birdshot retinochoroidopathy, retinal vasculitis, sympathetic ophthalmia, multifocal choroiditis with panuveitis. Prior to study screening, potential subjects must have been evaluated and screened for infectious etiologies by the investigators, possibly as part of standard clinical acre; all testing to rule out infectious causes must be performed within 3 months of screening for the STOP-UVEITIS study.
  • Currently active and uncontrolled uveitis (of the types mentioned above) that at the determination of the investigator, requires the initiation of corticosteroid monotherapy at a dose of ≥ 10 mg/day (or equivalent) or prednisone therapy and immunomodulatory therapy or injections of corticosteroid (intravitreal or periocular); or uveitis in subjects for whom oral corticosteroid is contraindicated, relatively or absolutely.
  • Evidence of active non-infectious ocular inflammation, that at the determination of investigator, requires therapy (e.g. vitreous cells, vitreous haze, retinal vasculitis, chorioretinitis). Such evidence can be documented by clinical examination, photography, or ancillary testing (e.g. fluorescein angiography, ICG, optical coherence tomography). As long as the investigator determines that the degree of inflammation can be monitored for regression or progression, the inflammation criterion can be met.
  • Not planning to undergo elective ocular surgery during the first 6 months of the study.

Exclusion Criteria:

  • Any significant ocular disease that could compromise vision in the study eye. These include, but are not limited to:

    • Diabetic retinopathy: proliferative diabetic retinopathy (PDR) or non-proliferative diabetic retinopathy (NPDR) that compromise the vision.
    • Age-related macular degeneration;
    • Myopic degeneration with active subfoveal choroidal neovascularization.
    • Advanced glaucoma status post trabeculectomy or tube/valve placement
  • Any of the following treatments within 90 days prior to Day 0 or anticipated use of any of the following treatments to the study eye:

    • Intravitreal injections (including but not limited to steroids or anti-vascular endothelial growth factors);
    • Posterior subtenon's steroids
  • Intraocular surgery within 90 days prior to Day 0 in the study eye;
  • Capsulotomy within 30 days prior to Day 0 in the study eye;
  • History of vitreoretinal surgery or scleral buckling
  • Any ocular surgery (including cataract extraction or capsulotomy) of the study eye anticipated within the first 180 days following Day 0;
  • Intraocular pressure ≥25 mmHg in the study eye (glaucoma patients maintained on no more than 2 topical medications with IOP <25 mmHg are allowed to participate);
  • Pupillary dilation inadequate for quality stereoscopic fundus photography in the study eye;
  • Media opacity that would limit clinical visualization;
  • Presence of any form of ocular malignancy in the study eye, including choroidal melanoma;
  • History of herpetic infection in the study eye or adnexa;
  • Presence of known active or inactive toxoplasmosis in either eye;
  • Ocular or periocular infection in either eye;
  • Participation in other investigational drug or device clinical trials within 30 days prior to Day 0, or planning to participate in other investigational drug or device clinical trials within 180 days following Day 0. This includes both ocular and non-ocular clinical trials
  • Major surgery (including joint surgery) within 8 weeks prior to screening or planned major surgery within 6 months following randomization
  • Prior treatment with any cell-depleting therapies, including investigational agents or approved therapies, some examples are CAMPATH, anti-CD4, anti-CD5, anti¬CD3, anti-CD19 and anti-CD20
  • Treatment with intravenous gamma globulin, plasmapheresis or Prosorba column within 6 months of baseline
  • Immunization with a live/attenuated vaccine within 4 weeks prior to baseline
  • Previous treatment with TCZ
  • Any previous treatment with alkylating agents such as chlorambucil, or with total lymphoid irradiation
  • History of severe allergic or anaphylactic reactions to human, humanized or murine monoclonal antibodies
  • Evidence of serious uncontrolled concomitant cardiovascular, nervous system, pulmonary (including obstructive pulmonary disease), renal, hepatic, endocrine (include uncontrolled diabetes mellitus) or gastrointestinal disease (including complicated diverticulitis, ulcerative colitis, or Crohn‟s disease)
  • Current liver disease as determined by principal investigator unless related to primary disease under investigation
  • Known active current or history of recurrent bacterial, viral, fungal, mycobacterial or other infections (including but not limited to tuberculosis and atypical mycobacterial disease, Hepatitis B and C, and herpes zoster, but excluding fungal infections of nail beds)
  • Any major episode of infection requiring hospitalization or treatment with IV antibiotics within 4 weeks of screening or oral antibiotics within 2 weeks prior to screening
  • Active TB requiring treatment within the previous 3 years. Patients should be screened for latent TB and, if positive, treated following local practice guidelines prior to initiating TCZ. Patients treated for tuberculosis with no recurrence in 3 years are permitted
  • Primary or secondary immunodeficiency (history of or currently active)
  • Evidence of active malignant disease, malignancies diagnosed within the previous 5 years (including hematological malignancies and solid tumors, except basal and squamous cell carcinoma of the skin or carcinoma in situ of the cervix uteri that has been excised and cured)
  • Pregnant women or nursing (breast feeding) mothers
  • Patients with reproductive potential not willing to use an effective method of contraception
  • History of alcohol, drug or chemical abuse within 1 year prior to screening.
  • Neuropathies or other conditions that might interfere with pain evaluation unless related to primary disease under investigation
  • Patients with lack of peripheral venous access
  • Serum creatinine > 1.6 mg/dL (141 μmol/L) in female patients and > 1.9 mg/dL(168 μmol/L) in male patients. Patients with serum creatinine values exceeding limits may be eligible for the study if their estimated glomerular filtration rates (GFR) are >30.
  • Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) > 1.5 times upper limit of normal (ULN)
  • Total Bilirubin > ULN
  • Platelet count < 100 x 109/L (100,000/mm3)
  • Hemoglobin < 85 g/L (8.5 g/dL; 5.3 mmol/L)
  • White Blood Cells < 3.0 x 109/L (3000/mm3)
  • Absolute Neutrophil Count < 2.0 x 109/L (2000/mm3)
  • Absolute Lymphocyte Count < 0.5 x 109/L (500/mm3)
  • Positive Hepatitis BsAg, or Hepatitis C antibody
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01717170

Contacts
Contact: Quan D Nguyen, MD, MSc. 410-502-0766 qnguyen4@jhmi.edu

Locations
United States, Maryland
Wilmer Eye Institute, Johns Hopkins University Not yet recruiting
Baltimore, Maryland, United States, 21287
Contact: Quan D Nguyen, MD, Msc.    410-502-0766    qnguyen4@jhmi.edu   
Sponsors and Collaborators
Johns Hopkins University
  More Information

No publications provided

Responsible Party: Quan Dong Nguyen, Associate Professor, Johns Hopkins University
ClinicalTrials.gov Identifier: NCT01717170     History of Changes
Other Study ID Numbers: ML28522
Study First Received: October 26, 2012
Last Updated: October 26, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by Johns Hopkins University:
Non-infectious Uveitis, Tocilizumab

Additional relevant MeSH terms:
Panuveitis
Uveitis
Chorioretinitis
Uveal Diseases
Eye Diseases
Retinitis
Retinal Diseases
Choroiditis
Choroid Diseases
Uveitis, Posterior

ClinicalTrials.gov processed this record on July 24, 2014