VIPER: Veterans Integrated Pain Evaluation Research
The purpose of the study is to learn about the causes of different types of pain that can occur in people who have had an amputation. By gathering information through blood tests, photographs, a nerve test, and questionnaires, we hope to de-code how each individual's special characteristics affect the type and amount of pain they experience in their amputated limb.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||VIPER: Veterans Integrated Pain Evaluation Research- Molecular Subtypes of Chronic Pain Syndromes|
- Proteomics [ Time Frame: 1 day ] [ Designated as safety issue: No ]To determine which proteins represent circulating qualitative and quantitative biomarkers of pain.
Biospecimen Retention: Samples With DNA
Blood draw will consist of, two BD™ P100 tubes (2x8.5mL=17mL) where the plasma will be separated by centrifuge then placed in a -80ºC freezer. Two RNA tubes (2 x 2.5mL=5mL) and one DNA tube (8.5mL) will be place first, in a -20ºC freezer for 24-36 hours then moved to a -80ºC freezer. All the blood samples will remain in a -80ºC freezer at the Department of Clinical Investigation(DCI) laboratory until they are sent to Duke University after every 8 subjects.
|Study Start Date:||January 2012|
|Primary Completion Date:||October 2013 (Final data collection date for primary outcome measure)|
Studies have already shown that pain following amputation might be caused by differences in a person's genes. This study may help us find out how genes affect the way you feel pain and why you may feel more or less or different kinds of pain than another person with a similar amputation. What we learn in this research study may lead to discoveries as to why some painkillers work better for some people than others.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01715766
|United States, Maryland|
|Walter Reed National Military Medical Center|
|Bethesda, Maryland, United States, 20889|