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Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
Collaborator:
German Sport University, Cologne
Information provided by (Responsible Party):
Klaus Kenn, Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier:
NCT01715337
First received: October 24, 2012
Last updated: April 14, 2014
Last verified: April 2014
  Purpose

Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.


Condition Intervention
Chronic Obstructive Pulmonary Disease
Other: pulmonary rehabilitation

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Pulmonary Rehabilitation on Muscle Fibre Composition and Capillaries in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Resource links provided by NLM:


Further study details as provided by Klinikum Berchtesgadener Land der Schön-Kliniken:

Primary Outcome Measures:
  • Change in the amount of capillaries in muscle fibre type I [ Time Frame: change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Change in the amount of capillaries in muscle fibre type IIa [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]
  • Change in the cross-sectional area of muscle fibre type I [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]
  • Change in the cross-sectional area of muscle fibre type IIa [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]

Enrollment: 20
Study Start Date: February 2010
Study Completion Date: April 2014
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
pulmonary rehabilitation Other: pulmonary rehabilitation
3-week rehabilitation including exercise training, breathing therapy, psychosocial support, medical treatment etc.

  Eligibility

Ages Eligible for Study:   40 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic obstructive pulmonary disease
  • FEV1%pred. < 50%

Exclusion Criteria:

  • acute exacerbation
  • exacerbation in the last 4 weeks
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01715337

Locations
Germany
Schön Klinik Berchtesgadener Land
Schönau am Königssee, Germany, 83471
Sponsors and Collaborators
Klinikum Berchtesgadener Land der Schön-Kliniken
German Sport University, Cologne
Investigators
Study Chair: Klaus Kenn, Dr. med. Klinikum Berchtesgadener Land
  More Information

No publications provided

Responsible Party: Klaus Kenn, Head physician (department of pneumology), Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier: NCT01715337     History of Changes
Other Study ID Numbers: COPD muscle 2011
Study First Received: October 24, 2012
Last Updated: April 14, 2014
Health Authority: Germany: Ethics Commission

Keywords provided by Klinikum Berchtesgadener Land der Schön-Kliniken:
muscle fibre
capillary
rehabilitation
exercise training

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on November 20, 2014