Effects of Rehabilitation on Muscle Fibre Composition and Capillaries in Chronic Obstructive Pulmonary Disease (COPD) Patients

This study has been completed.
Sponsor:
Collaborator:
German Sport University, Cologne
Information provided by (Responsible Party):
Klaus Kenn, Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier:
NCT01715337
First received: October 24, 2012
Last updated: April 14, 2014
Last verified: April 2014
  Purpose

Pulmonary rehabilitation has been established as an evidence-based and recommended therapy in patients with chronic obstructive pulmonary disease (COPD). The aim of our study is to show a potential change in muscle fibre composition and in the amount of capillaries in quadriceps muscle from pre tob post 3-week rehabilitation. Pulmonary rehabilitation includes standardised exercise training, e.g. cycling and strength training for major muscle groups.


Condition Intervention
Chronic Obstructive Pulmonary Disease
Other: pulmonary rehabilitation

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Effects of Pulmonary Rehabilitation on Muscle Fibre Composition and Capillaries in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Resource links provided by NLM:


Further study details as provided by Klinikum Berchtesgadener Land der Schön-Kliniken:

Primary Outcome Measures:
  • Change in the amount of capillaries in muscle fibre type I [ Time Frame: change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Change in the amount of capillaries in muscle fibre type IIa [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]
  • Change in the cross-sectional area of muscle fibre type I [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]
  • Change in the cross-sectional area of muscle fibre type IIa [ Time Frame: Change from pre (day 1) to post rehabilitation (day 21) ] [ Designated as safety issue: No ]

Enrollment: 20
Study Start Date: February 2010
Study Completion Date: April 2014
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
pulmonary rehabilitation Other: pulmonary rehabilitation
3-week rehabilitation including exercise training, breathing therapy, psychosocial support, medical treatment etc.

  Eligibility

Ages Eligible for Study:   40 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • chronic obstructive pulmonary disease
  • FEV1%pred. < 50%

Exclusion Criteria:

  • acute exacerbation
  • exacerbation in the last 4 weeks
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01715337

Locations
Germany
Schön Klinik Berchtesgadener Land
Schönau am Königssee, Germany, 83471
Sponsors and Collaborators
Klinikum Berchtesgadener Land der Schön-Kliniken
German Sport University, Cologne
Investigators
Study Chair: Klaus Kenn, Dr. med. Klinikum Berchtesgadener Land
  More Information

No publications provided

Responsible Party: Klaus Kenn, Head physician (department of pneumology), Klinikum Berchtesgadener Land der Schön-Kliniken
ClinicalTrials.gov Identifier: NCT01715337     History of Changes
Other Study ID Numbers: COPD muscle 2011
Study First Received: October 24, 2012
Last Updated: April 14, 2014
Health Authority: Germany: Ethics Commission

Keywords provided by Klinikum Berchtesgadener Land der Schön-Kliniken:
muscle fibre
capillary
rehabilitation
exercise training

Additional relevant MeSH terms:
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on April 17, 2014