Near-Infrared Spectroscopic (NIRS) Tissue Oxygen Saturation and the Vascular Occlusion Test in Cardiac Surgery Patients

This study has been completed.
Information provided by:
London Health Sciences Centre Identifier:
First received: October 23, 2012
Last updated: October 25, 2012
Last verified: October 2012

Tissue oxygen saturation (StO2) and its recovery during a vascular occlusion test (VOT) will be measured in elective cardiac surgery patients undergoing cardiopulmonary bypass using a non-invasive near infrared spectrometry (NIRS) machine. The purpose of this study is to determine whether changes in VOT measurements occur in patients during cardiac surgery.

Vascular Occlusion Test

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by London Health Sciences Centre:

Primary Outcome Measures:
  • VOT reperfusion slope [ Time Frame: Intra-operative (within 12 hours) ] [ Designated as safety issue: No ]
    Reperfusion slope as measured during vascular occlusion test in units of %/s

Enrollment: 13
Study Start Date: February 2011
Study Completion Date: September 2011
VOT on bypass


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Elective cardiac surgery patients undergoing coronary artery bypass and valve surgery using cardiopulmonary bypass.


Inclusion Criteria:

  • Adult, elective cardiac surgery patients
  • Procedure using cardiopulmonary bypass

Exclusion Criteria:

  • Contraindication to pneumatic cuff inflation
  • Pregnant
  • Significant peripheral vascular disease of the arms
  • Emergency surgery
  Contacts and Locations
Please refer to this study by its identifier: NCT01712750

Canada, Ontario
London Health Sciences Centre
London, Ontario, Canada, N6A 5A5
Sponsors and Collaborators
London Health Sciences Centre
Principal Investigator: John M Murkin, MD, FRCPC London Health Sciences Centre
  More Information

No publications provided Identifier: NCT01712750     History of Changes
Other Study ID Numbers: REB-17456
Study First Received: October 23, 2012
Last Updated: October 25, 2012
Health Authority: Canada: Ethics Review Committee

Keywords provided by London Health Sciences Centre:
Regional tissue oximetry
Cardiopulmonary bypass
Cardiac surgical procedures processed this record on April 17, 2014