The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.
The overall purpose is to explore the link between the gut and the bones by investigating meal stimulated changes in the blood level of a number of hormones and markers related to intestinal growth and bone turnover in patients undergoing surgery for obesity (gastric bypass). The hormones will be measured in blood samples taken before and after surgery. The results are compared with changes in body weight and body composition as measured by DEXA scanning.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||The Effect of Gastric Bypass Surgery on Gut Hormones Related to Bone Remodeling and Intestinal Growth.|
- Meal stimulated changes in gut hormones and bone markers. [ Time Frame: Before surgery and 4 weeks and 6 months after surgery. ] [ Designated as safety issue: No ]
- Changes in bone mass and body composition. [ Time Frame: Before surgery and 6 months after surgery. ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Plasma and serum samples are retained.
|Study Start Date:||October 2011|
|Estimated Study Completion Date:||December 2012|
|Estimated Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
Meal test and dexa scan
Other: Meal test and dexa scan
Body composition is determined by whole body deca scan and bone mineral density is determined dy dexa scans of the lumbar spine and the proximal femur.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01700686
|Hospital of Roskilde-Koege, The University of Copenhagen|
|Koege, Denmark, DK-4600|
|Principal Investigator:||Bolette Hartmann, PhD||University of Copenhagen|