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Genetic & Environmental Determinants Of Immune Phenotype Variance: Establishing A Path Towards Personalized Medicine (LabExMI)

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2012 by Institut Pasteur
Sponsor:
Information provided by (Responsible Party):
Institut Pasteur
ClinicalTrials.gov Identifier:
NCT01699893
First received: September 21, 2012
Last updated: October 3, 2012
Last verified: September 2012
  Purpose

The purpose of this study is to assess the determinants of immunologic variance within the general healthy population.


Condition Intervention
Individuality
Other: unique arm

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Genetic & Environmental Determinants Of Immune Phenotype Variance: Establishing A Path Towards Personalized Medicine

Further study details as provided by Institut Pasteur:

Primary Outcome Measures:
  • Measurement of cytokine/chemokine stimulated by 40 pattern-recognition receptors agonists (PRR agonists) or immune stimulators. [ Time Frame: V2 (28days after V1) ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Determination of genotype-to-phenotype associations at a mechanistic level [ Time Frame: 4 days after V0 ] [ Designated as safety issue: No ]

Estimated Enrollment: 1200
Study Start Date: September 2012
Estimated Study Completion Date: December 2018
Estimated Primary Completion Date: December 2018 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: unique arm
  • At V0: 1500 will be screened
  • At V1: 1000 subjects will be performed following samples: blood, nasal swab,stool. 500 subjects among 1000 will be performed one additional sample (Skin Biopsy)
  • At V2: only the 500 subjects having performing the skin biopsy at V1 will come at V2 to perform blood, nasal swab and stool samples
Other: unique arm
blood, nasal swab, skin biopsy, stool samples

Detailed Description:

Susceptibility to infections, disease severity, and response to medical therapies and vaccines are highly variable from one individual to another. While the question of variance in human populations continues to be a focal point of scientific research, medical practices and public health policies typically take a 'one size fits all' model to disease management and drug development.

Individual heterogeneity in the immune response can have an enormous impact on the likelihood to respond to therapy or the development of side effects secondary to vaccine administration. Because of the complexity of immune responses in the individual and within the population, it has not been possible thus far to define the parameters (genetic or environmental) that constitute a healthy immune system and its natural occurring variability.

Efforts to restore the 'personal' in medical care are the current challenge, and the driving vision of the project, to which the current study belongs.

In order to realize the promise of personalized medicine, an in-depth understanding of the determinants of heterogeneity in host response to stress is required.

  Eligibility

Ages Eligible for Study:   20 Years to 69 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Subjects considered as healthy by the investigator based on medical history, clinical examination, laboratory results and ECG (blood sampling for laboratory assessments and ECG should be done at V0 and only after signed informed consent).
  2. Subjects who, according to the investigator, can and will comply with the requirements of the protocol and are available for all scheduled visits at the investigational site.
  3. Healthy male or female aged between 20 and 69 (included) years
  4. Metropolitan French origin for 3 generations 5)18.5 ≤BMI ≤ 32 kg/m² (Appendix 18.6)

6)Ability to give their informed consent in writing 7)Must understand spoken and written French 8)Affiliated to the French social security or assimilated regimens 9)Registered on the French "Fichier des Volontaires se prêtant à la Recherche Biomédicale (VRB)"

Exclusion Criteria:

  1. Subjects who can not participate according to their status on the registry mentioned at Art L. 1121-16 of the French Public Health Code
  2. Participation in another clinical study in the last 3 months in which the subject has been exposed to an investigational product (pharmaceutical product or placebo or medical device) or concurrent participation in another clinical study during the study period
  3. Relatedness to previously recruited individuals in the study cohort
  4. Travel in (sub-)tropical countries within the last 3 months
  5. For women: pregnant or breastfeeding or intending to become pregnant or peri-menopausal*

    * Peri-menopausal women as defined by menstrual irregularity: either a change in the menstrual cycle length of more than seven days (early perimenopause) or two or more missed periods with an interval of 60 days or more between periods (late perimenopause) (Stages of Reproductive Aging Workshop, STRAW)(11)

  6. Any physical exercise within the last 8 hours before inclusion (V1) and before (V2)
  7. Subjects following a special diet for medical reasons as prescribed by a GP or dietician (e.g. calorie restricted or weight-loss diet for significant overweight, cholesterol lowering diet or subjects suffering from any clinically diagnosed food allergy or intolerance)
  8. Alcohol abuse (more than 50 g of pure ethanol per day: for example, more than 4 x 150 mL glasses of wine, more than 4 x 250 mL glasses of beer, more than 4 x 40 mL glasses of high alcohol content drinks)
  9. Illicit drug use or substance abuse within 3 months prior to inclusion
  10. Presence of evidence of neurological or psychiatric diagnoses which, although stable, are deemed by the investigator to render the potential subject unable/unlikely to participate in the study satisfactorily.
  11. Severe/chronic/recurrent pathological conditions,
  12. Chronic administration (defined as more than 14 days) of immunosuppressants or other immune-modifying drugs within the 6 months prior to the inclusion. For corticosteroids, this will mean a dose equivalent to 20 mg/day of prednisone or equivalent for > 2 weeks (inhaled and topical steroids allowed)
  13. Chronic administration of NSAIDs, including aspirin: prolonged intake (> 2 weeks) within 6 months before study or any intake within the 7 days preceding skin biopsy [exception for low dose aspirin: maximum 250mg/daily, see 8.1]
  14. Receipt of any vaccination 3 months before the inclusion or planning to receive any vaccination during the study
  15. Receipt of blood products or immunoglobulins within 3 months prior the inclusion or planning to receive blood products or immunoglobulins during the study
  16. Hemoglobin measurement less than 10.0 g/dL for women and less than 11.5 g/dL for men
  17. Platelet count less than 120.000/mm3
  18. ALAT and/or ASAT > 3 times the upper limit of the norm (ULN)
  19. Allergy to lidocaine
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01699893

Locations
France
BIOTRIAL Recruiting
Rennes, France, 35042
Contact: Louis Guillaume MARQUIER       Louis-Guillaume.Marquier@biotrial.com   
Principal Investigator: Nicolas FAUCHOUX, MD         
Sponsors and Collaborators
Institut Pasteur
Investigators
Study Chair: Matthew ALBERT Institut Pasteur / Inserm
Study Chair: Lluis QUINTANA-MURCI Institut Pasteur / CNRS
Principal Investigator: Nicolas FAUCHOUX Biotrial Rennes
  More Information

No publications provided

Responsible Party: Institut Pasteur
ClinicalTrials.gov Identifier: NCT01699893     History of Changes
Other Study ID Numbers: 2012-A00238-35
Study First Received: September 21, 2012
Last Updated: October 3, 2012
Health Authority: France: Agence Nationale de Sécurité du Médicament et des produits de santé

ClinicalTrials.gov processed this record on November 25, 2014