Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery (HSL2012-06)
Verified September 2012 by Hospital Sirio-Libanes
Information provided by (Responsible Party):
Frederico Perego Costa, Hospital Sirio-Libanes
First received: September 12, 2012
Last updated: September 19, 2012
Last verified: September 2012
A retrospective study based on analysis of medical records of patients with hepatocellular carcinoma treated at the Hospital Sírio-Libanês (Sao Paulo-Brazil) between 2001 and 2011 with diagnosis confirmed by imaging or histological specimen underwent surgical resection with curative intent. The study aims to determine the prognostic value of vascular complications related to cancer and to evaluate the survival rate of these patients, comparing the data with those reported in the literature.
Portal Vein Thrombosis
Hepatic Portal Vein Tumor Invasion
||Observational Model: Cohort
Time Perspective: Retrospective
||Prognostic Value Related to the Presence of Thrombosis or Portal Vein Invasion in Patients With Hepatocellular Carcinoma Submitted to Surgery
Primary Outcome Measures:
Secondary Outcome Measures:
- Survival rate in years [ Time Frame: 1 to 3 years ] [ Designated as safety issue: Yes ]
Determination of the survival rate within 1 to 3 years for those submitted to curative hepatectomy.
- Relation established between survival and degree of underlying liver dysfunction [ Time Frame: 1 to 3 years ] [ Designated as safety issue: Yes ]
Investigate a possible relationship between survival and degree of underlying liver dysfunction in patients with thrombosis or portal vein invasion in patients undergoing curative hepatectomy.
| Estimated Enrollment:
| Study Start Date:
Hepatocellular carcinoma underwent surgery
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Patients diagnosed with hepatocellular carcinoma confirmed by imaging or histological specimen underwent surgical resection with curative intent with the presence of venous outflow obstruction, either by direct tumor invasion or thrombosis, on portal vein or one of its main vessels.
- hepatocellular carcinoma confirmed by imaging or histological specimen underwent surgical resection, with or without hepatic cirrhosis association;
- presence of venous outflow obstruction, either by direct tumor invasion or thrombosis, on portal vein or one of its main vessels;
- Patients undergoing prior systemic treatment;
- Patients presenting incomplete data that do not allow their classification according to the stratification models;
- Patients whose information of progression or death can not be recovered;
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01690715
|São Paulo, Brazil |
|Contact: Frederico Costa 55 11 3155 8800 |
|Principal Investigator: Frederico Costa, Md |
No publications provided
||Frederico Perego Costa, Attending physician, Hospital Sirio-Libanes
History of Changes
|Other Study ID Numbers:
|Study First Received:
||September 12, 2012
||September 19, 2012
||Brazil: National Committee of Ethics in Research
Keywords provided by Hospital Sirio-Libanes:
Portal Vein Invasion
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on August 26, 2014
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Embolism and Thrombosis
Digestive System Neoplasms
Neoplasms by Site
Digestive System Diseases