Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study
The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.
Non ST Elevation Myocardial Infarction
ST Elevation Myocardial Infarction
Myocardial Infarction Not Otherwise Specified
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study)|
- Rate of stable angina [ Time Frame: Cohort followed up for average of 7 years ] [ Designated as safety issue: No ]Incidence of stable angina in study population
- Rate of unstable angina [ Time Frame: Cohort followed up for average of 7 years ] [ Designated as safety issue: No ]Incidence of unstable angina in study population
- Rate of non ST elevation myocardial infarction [ Time Frame: Cohort followed up for average of 7 years ] [ Designated as safety issue: No ]Incidence of non ST elevation myocardial infarction
|Study Start Date:||January 2001|
|Estimated Study Completion Date:||December 2012|
|Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
Initially healthy patients in General Practise Research Database (GPRD) meeting the inclusion criteria at any point between 1st January 2001 and 25th March 2010
The role of lipids (cholesterol and triglycerides) as risk factors for cardiovascular events is well-documented. The Emerging Risk Factors Collaboration found approximately log-linear adjusted associations of cholesterol concentrations with risks of first-time non-fatal myocardial infarction; coronary heart disease (CHD) death; ischaemic, haemorrhagic and unclassified stroke. They also found that triglycerides concentration was not independently related with CHD risk after controlling for HDL cholesterol (HDL-C), non-HDL-C, and other standard risk factors. The Prospective Studies Collaboration found that Higher HDL-C and lower non-HDL-C levels were approximately independently associated with lower ischaemic heart disease mortality. By focusing on broad outcomes these large meta-analyses conflate the association between development of the different cardiovascular disease (CVD) phenotypes, disease progression and mortality from cardiovascular causes.
With linked electronic health records, we have the potential for a cohort with sufficient size and clinical detail to investigate the association between lipid concentrations and initial presentation of a range of CVD phenotypes across cerebral, coronary, abdominal and peripheral arterial circulations.