Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by Region Skane
Sponsor:
Information provided by (Responsible Party):
Region Skane
ClinicalTrials.gov Identifier:
NCT01686984
First received: September 13, 2012
Last updated: March 4, 2014
Last verified: February 2014
  Purpose

The purpose of this study is to investigate how inspiratory flow pattern influences CO2 elimination in people without primary lung disease.

The hypothesis is that a long mean distribution time, caused by a long postinspiratory pause and high end-inspiratory flow, will promote CO2 exchange in the alveoli.


Condition Intervention
Pulmonary Gas Exchange
Carbon Dioxide
Other: Altered breath

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Influence of Inspiratory Flow Pattern on Exchange of Carbon Dioxide in Humans Without Primary Lung Disease

Resource links provided by NLM:


Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Carbon dioxide elimination in a ventilator assisted breath. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Blood CO2 concentration. [ Time Frame: 30 minutes ] [ Designated as safety issue: No ]

Estimated Enrollment: 10
Study Start Date: September 2012
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: September 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Altered breath
The group where the investigators alter the inspiratory and expiratory aspects of a ventilated breath.
Other: Altered breath

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • No known primary lung disease

Exclusion Criteria:

  • Primary lung disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01686984

Contacts
Contact: Gunnar Malmkvist, Med.Dr +4646-171035 gunnar.malmkvist@skane.se

Locations
Sweden
Division of Brain, Heart and Lungs, Neurosurgical Clinic, Skane University Hospital, Lund Recruiting
Lund, Skane, Sweden, 22185
Contact: Samuel Allvin, Med. Student    +46706607477    samuelallvin@gmail.com   
Sponsors and Collaborators
Region Skane
Investigators
Principal Investigator: Mikael Bodelsson, Professor Division of Anesthesia, Skane University Hospital, Lund, Sweden
  More Information

No publications provided

Responsible Party: Region Skane
ClinicalTrials.gov Identifier: NCT01686984     History of Changes
Other Study ID Numbers: 2012/381
Study First Received: September 13, 2012
Last Updated: March 4, 2014
Health Authority: Sweden: Swedish Medical Product Agency

Additional relevant MeSH terms:
Lung Diseases
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on October 29, 2014