Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Javier Gonzalez, Northumbria University
ClinicalTrials.gov Identifier:
NCT01682343
First received: September 6, 2012
Last updated: September 10, 2012
Last verified: September 2012
  Purpose

The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.


Condition Intervention
Nutritional and Metabolic Diseases
Dietary Supplement: Calcium

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: Effect of High-calcium Intake on Appetite, Insulinemia and Incretins

Resource links provided by NLM:


Further study details as provided by Northumbria University:

Primary Outcome Measures:
  • Subjective appetite ratings [ Time Frame: 3 hour ] [ Designated as safety issue: No ]
    Subjective ratings of appetite assessed by visual analogue scales.


Secondary Outcome Measures:
  • Serum insulin concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for serum insulin following breakfast consumption

  • Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption

  • Plasma glucagon-like peptide-1 concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]
    2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption


Other Outcome Measures:
  • Total fat oxidised during 60 min of exercise (g) [ Time Frame: 1 hour ] [ Designated as safety issue: No ]
    Assessed by indirect calorimetry


Enrollment: 10
Study Start Date: May 2012
Study Completion Date: August 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Placebo
Breakfast consisting of milk-based porridge with a normal calcium content.
Experimental: High-Calcium
As control, but with a high-calcium content.
Dietary Supplement: Calcium
Milk-calcium supplement

Detailed Description:

Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • recreationally active
  • male

Exclusion Criteria:

  • food intolerances/allergies
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01682343

Locations
United Kingdom
Northumbria University
Newcastle upon Tyne, Tyne on Wear, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Investigators
Principal Investigator: Javier T Gonzalez, MRes Northumbria University
  More Information

No publications provided

Responsible Party: Javier Gonzalez, PhD Student, Northumbria University
ClinicalTrials.gov Identifier: NCT01682343     History of Changes
Other Study ID Numbers: 32AN2
Study First Received: September 6, 2012
Last Updated: September 10, 2012
Health Authority: United Kingdom: Research Ethics Committee

Additional relevant MeSH terms:
Metabolic Diseases
Calcium, Dietary
Incretins
Bone Density Conservation Agents
Physiological Effects of Drugs
Pharmacologic Actions
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists

ClinicalTrials.gov processed this record on April 23, 2014