Effect of High-calcium Intake on Appetite, Insulinemia and Incretins
This study has been completed.
Sponsor:
Northumbria University
Information provided by (Responsible Party):
Javier Gonzalez, Northumbria University
ClinicalTrials.gov Identifier:
NCT01682343
First received: September 6, 2012
Last updated: September 10, 2012
Last verified: September 2012
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Purpose
The purpose of this study is to investigate the appetite, insulin and incretin hormone responses to a high-calcium meal.
| Condition | Intervention |
|---|---|
|
Nutritional and Metabolic Diseases |
Dietary Supplement: Calcium |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Intervention Model: Crossover Assignment Masking: Double Blind (Subject, Investigator) Primary Purpose: Basic Science |
| Official Title: | Effect of High-calcium Intake on Appetite, Insulinemia and Incretins |
Resource links provided by NLM:
Further study details as provided by Northumbria University:
Primary Outcome Measures:
- Subjective appetite ratings [ Time Frame: 3 hour ] [ Designated as safety issue: No ]Subjective ratings of appetite assessed by visual analogue scales.
Secondary Outcome Measures:
- Serum insulin concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for serum insulin following breakfast consumption
- Plasma glucose-dependent insulinotropic peptide concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for plasma glucose-dependent insulinotropic peptide following breakfast consumption
- Plasma glucagon-like peptide-1 concentration [ Time Frame: 2 hour ] [ Designated as safety issue: No ]2 hour area under the curve for plasma glucagon-like peptide-1 following breakfast consumption
Other Outcome Measures:
- Total fat oxidised during 60 min of exercise (g) [ Time Frame: 1 hour ] [ Designated as safety issue: No ]Assessed by indirect calorimetry
| Enrollment: | 10 |
| Study Start Date: | May 2012 |
| Study Completion Date: | August 2012 |
| Primary Completion Date: | August 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Placebo Comparator: Placebo
Breakfast consisting of milk-based porridge with a normal calcium content.
|
|
|
Experimental: High-Calcium
As control, but with a high-calcium content.
|
Dietary Supplement: Calcium
Milk-calcium supplement
|
Detailed Description:
Participants will be provided with control and high-calcium meals. Insulin, appetite, glucagon-like peptide-1 and glucose-dependent insulinotropic peptide responses will be assessed, along with rates of substrate oxidation.
Eligibility| Genders Eligible for Study: | Male |
| Accepts Healthy Volunteers: | Yes |
Criteria
Inclusion Criteria:
- recreationally active
- male
Exclusion Criteria:
- food intolerances/allergies
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01682343
Locations
| United Kingdom | |
| Northumbria University | |
| Newcastle upon Tyne, Tyne on Wear, United Kingdom, NE1 8ST | |
Sponsors and Collaborators
Northumbria University
Investigators
| Principal Investigator: | Javier T Gonzalez, MRes | Northumbria University |
More Information
No publications provided
| Responsible Party: | Javier Gonzalez, PhD Student, Northumbria University |
| ClinicalTrials.gov Identifier: | NCT01682343 History of Changes |
| Other Study ID Numbers: | 32AN2 |
| Study First Received: | September 6, 2012 |
| Last Updated: | September 10, 2012 |
| Health Authority: | United Kingdom: Research Ethics Committee |
Additional relevant MeSH terms:
|
Metabolic Diseases Calcium, Dietary Incretins Bone Density Conservation Agents |
Physiological Effects of Drugs Pharmacologic Actions Hormones Hormones, Hormone Substitutes, and Hormone Antagonists |
ClinicalTrials.gov processed this record on June 13, 2013