Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension
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Purpose
Preliminary data from the investigator's lab identified novel patterns of differential DNA methylation in genes regulating cardiovascular and metabolic function in blood from women during the first trimester of pregnancy who were destined to develop preeclampsia (PE) in the third trimester. Further, common patterns of differential DNA methylation were found in the common genes from placental tissue at time of birth in the same women after diagnosis with PE, suggesting that the epigenomic patterns that predict pregnancy-induced hypertension may also underlie the development of chronic hypertension years after.
It is unknown whether aberrant DNA methylation in pregnancy-induced hypertension is the mechanism by which chronic hypertension develops in these women remote from pregnancy nor is it known if hypertension remote from PE is as responsive to therapeutic treatment of hypertension compared to women who develop hypertension without history of PE. The investigators plan to objectively test the central hypothesis and attain the objective of this project
| Condition |
|---|
|
Preeclampsia Hypertension Pregnancy Induced Hypertension |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Observational Study of Epigenomic Dysregulation in Preeclampsia-Associated Chronic Hypertension |
Sputum and peripheral blood will be collected for DNA extraction and epigenetic analyses.
| Estimated Enrollment: | 80 |
| Study Start Date: | May 2012 |
| Estimated Primary Completion Date: | March 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
History of Preeclampsia
Chronic hypertension with history of preeclampsia Chronic hypertension without history of preeclampsia
|
Eligibility| Ages Eligible for Study: | 30 Years to 65 Years |
| Genders Eligible for Study: | Female |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Females diagnosed with chronic hypertension with a prior pregnancy
Inclusion Criteria:
- Female gender
- history of prior pregnancy
- diagnosis of chronic hypertension
- current treatment of chronic hypertension
- age 30 - 50 years old
Exclusion Criteria:
- presence of comorbid conditions that influence cardiovascular health (SLE, congenital cardiac anomalies
Contacts and Locations| United States, North Dakota | |
| USDA Grand Forks Human Research Nutrition Center | Recruiting |
| Grand Forks, North Dakota, United States, 58203 | |
| Contact: Julie Dahlman, RN, BSN 701-795-8300 julie.dahlman@ars.usda.gov | |
More Information
No publications provided
| Responsible Party: | Cindy Anderson, PhD, WHNP-BC, FAAN, USDA Grand Forks Human Nutrition Research Center |
| ClinicalTrials.gov Identifier: | NCT01682304 History of Changes |
| Other Study ID Numbers: | GFHNRC611 |
| Study First Received: | September 5, 2012 |
| Last Updated: | March 13, 2013 |
| Health Authority: | United States: Federal Government |
Keywords provided by USDA Grand Forks Human Nutrition Research Center:
|
preeclampsia hypertension blood pressure pregnancy induced hypertension chronic hypertension |
Additional relevant MeSH terms:
|
Hypertension Pre-Eclampsia Hypertension, Pregnancy-Induced |
Vascular Diseases Cardiovascular Diseases Pregnancy Complications |
ClinicalTrials.gov processed this record on May 22, 2013