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Collection of Blood and Bone Marrow From Patients With Aplastic Anemia for Analysis of Adhesion Molecules, Chemokines and Their Receptors

This study is currently recruiting participants.
Verified September 2012 by Shandong University
Sponsor:
Information provided by (Responsible Party):
Ming Hou, Shandong University
ClinicalTrials.gov Identifier:
NCT01680055
First received: September 3, 2012
Last updated: NA
Last verified: September 2012
History: No changes posted
  Purpose

This study is designed to collect bone marrow and/or peripheral blood cells and plasma, for the analysis of adhesion molecules, chemokines and their receptors from newly-diagnosed aplastic anemia patients, and patients treated with antithymocyte globulin plus cyclosporine


Condition
Aplastic Anemia
Healthy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Shandong University:

Primary Outcome Measures:
  • hematologic response [ Time Frame: 6 months following antithymocyte globulin plus cyclosporine treatment ] [ Designated as safety issue: No ]
    hematologic response at 6 months following antithymocyte globulin plus cyclosporine treatment, defined as no longer meeting the criteria for severe aplastic anemia


Estimated Enrollment: 70
Study Start Date: February 2009
Estimated Study Completion Date: November 2012
Groups/Cohorts
AA-ATG
Acquired Aplastic Anemia Patients Treated with Antithymocyte Globulin plus Cyclosporine

  Eligibility

Ages Eligible for Study:   16 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Patients With Aplastic Anemia

Criteria

Inclusion Criteria:

  • patients who fulfilled entry criteria of acquired aplastic anemia age range 16-70 years

Exclusion Criteria:

  • Patients complicated with diabetes, tumor, pregnancy, active infection, or connective tissue diseases, such as systemic lupus erythematosus.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01680055

Locations
China, Shandong
Qilu Hospital, Shandong University Recruiting
Jinan, Shandong, China, 250012
Contact: Jun Peng, MD     13553157577     junpeng88@sina.com.cn    
Principal Investigator: Ming Hou, MD            
Sponsors and Collaborators
Shandong University
  More Information

No publications provided

Responsible Party: Ming Hou, Director, Shandong University
ClinicalTrials.gov Identifier: NCT01680055     History of Changes
Other Study ID Numbers: Aplastic Anemia 1
Study First Received: September 3, 2012
Last Updated: September 3, 2012
Health Authority: China: National Natural Science Foundation

Additional relevant MeSH terms:
Anemia
Anemia, Aplastic
Hematologic Diseases
Bone Marrow Diseases

ClinicalTrials.gov processed this record on June 17, 2013