Involvement of Nervous System in Muscle Weakness in COPD Patients (DesCoM-1)
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Purpose
The purpose of this study is to determine whether nervous system alterations and motor drive failure can contribute to muscle weakness in COPD during voluntary movement. If necessary, we will look after the role of nocturnal hypoxia in these alterations.
| Condition |
|---|
|
Chronic Obstructive Pulmonary Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Phase 1 Impact of Nocturnal Desaturations on Central Motor Drive in COPD Patients: A New Insight on the Systemic Effects of the Disease. |
whole blood
| Estimated Enrollment: | 45 |
| Study Start Date: | July 2012 |
| Estimated Study Completion Date: | July 2013 |
| Estimated Primary Completion Date: | July 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
|
COPD nocturnal desaturator
COPD patients who spend 30% of the nigth with a SaO2 < 90%.
|
|
COPD no nocturnal desaturator
COPD patients who spend less than 30% of the night with a SaO2 < 90%
|
|
control group
healthy sedentary subjects
|
Detailed Description:
COPD is a common disease that induces many systemic repercussions. Among these, peripheral muscle dysfunction is particularly deleterious because it leads to the decreases of the level of activity and the quality of life for patients. Movement involves activation of many structures, from the instructor, i.e. the brain, to the effector, i.e. the muscle. Netherless, the studies which have described peripheral muscle dysfunction have been focused on the muscle, so they have proposed a reducing vision of the phenomenon. Other studies have reported cerebral alterations in COPD, like cognitive disturbance, increase of the neuronal conduction time, and decrease of the white matter density, and were associated with chronic hypoxemia. Such alterations are consistent with the existence of a decrease of the central motor drive during voluntary movement in COPD patients. Therefore the study will aim to determine precisely which mechanisms are involved in peripheral muscle dysfunction in copd.
Eligibility| Ages Eligible for Study: | 40 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Two groups of COPD patients and one group with healthy sedentary subjects
Inclusion Criteria:
- COPD Patients at stage 2 and 3
- Healthy sedentary subjects
Exclusion Criteria:
- Epilepsy, pace-maker, nervous disorders
Contacts and Locations| Contact: Francois FA Alexandre, PhD student | 0666678916 ext 0033 | francois.alexandre@fontalvie.fr |
| Contact: Alain AV Varray, Pr | 0411759070 ext 0033 | alain.varray@univ-montp1.fr |
| France | |
| Clinique du Souffle La Vallonie | Recruiting |
| Lodève, France, 34700 | |
| Contact: Francois FA Alexandre, PhD student 0666678916 ext 0033 francois.alexandre@fontalvie.fr | |
| Study Director: | Alain AV Varray, Pr | M2H laboratory, Montpellier |
More Information
No publications provided
| Responsible Party: | Groupe Fontalvie |
| ClinicalTrials.gov Identifier: | NCT01679782 History of Changes |
| Other Study ID Numbers: | FVIE_FA1 |
| Study First Received: | September 3, 2012 |
| Last Updated: | September 3, 2012 |
| Health Authority: | France: L’Agence nationale de sécurité du médicament et des produits de santé |
Keywords provided by Groupe Fontalvie:
|
COPD, nervous system, peripheral muscle dysfunction |
Additional relevant MeSH terms:
|
Lung Diseases Respiration Disorders Pulmonary Disease, Chronic Obstructive Lung Diseases, Obstructive Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 23, 2013