Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy
The purpose of this research study is to identify and study changes in muscle in people with facioscapulohumeral muscular dystrophy using magnetic resonance imaging and spectroscopy.
Facioscapulohumeral Muscular Dystrophy
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Magnetic Resonance Imaging and Spectroscopy Biomarkers for Facioscapulohumeral Muscular Dystrophy|
- No primary outcome as this is an observational study. [ Time Frame: 0 ] [ Designated as safety issue: No ]
|Study Start Date:||March 2012|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
This group consists of participants who have a diagnosis of facioscapulohumeral muscular dystrophy confirmed by genetic testing.
This group consists of participants without facioscapulohumeral muscular dystrophy who are age- and gender-matched to participants in the FSHD group.
This research study is being done to compare muscle imaging findings in people with facioscapulohumeral muscular dystrophy (FSHD) to people without FSHD. Both magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) will be used to evaluate skeletal muscle in research participants. MRS is a type of imaging used to measure the levels of different chemicals in body tissues. It is done as part of a routine clinical MR exam in other parts of the body such as the brain, but has yet not been widely used in the musculoskeletal system. This research is being done to assess the effectiveness of MRS and MRI in helping doctors measure the type and severity of musculoskeletal disease. The investigators also hope to use MRI and MRS in developing outcome measures that can be used in future clinical trials for FSHD.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01671865
|Contact: Doris G Leung, MDfirstname.lastname@example.org|
|Contact: Kathryn R Wagner, MD, PhDemail@example.com|
|United States, Maryland|
|Kennedy Krieger Institute||Recruiting|
|Baltimore, Maryland, United States, 21205|
|Principal Investigator: Kathryn R Wagner, MD, PhD|
|Sub-Investigator: Doris G Leung, MD|
|Principal Investigator:||Kathryn R Wagner, MD, PhD||Hugo W. Moser Research Institute at Kennedy Krieger, Inc.|